Contrast medium-induced pulmonary vascular hyperpermeability: Is aggravated in a rat climacterium model

Koji Tominaga, Yasufumi Kataoka, Toshiaki Sendo, Wakako Furuta, Midori Niizeki, Ryozo Oishi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


RATIONALE AND OBJECTIVES. To test whether climacterium influences adverse pulmonary reactions to contrast media, the authors investigated the effect of ioxaglate on pulmonary vascular permeability in ovariectomized rats as a climacterium model. METHODS. From 7 days after surgery, ovariectomized rats were treated with estradiol valerate or vehicle once per week for 3 weeks. At 28 days after surgery, ioxaglate, an ionic contrast medium, was intravenously injected at 1.5 mL/min in rats. Pulmonary vascular permeability was evaluated by measuring the amount of Evans blue dye in the lung tissue. RESULTS. Ioxaglate dose-dependently increased pulmonary vascular permeability in sham-operated and ovariectomized rats. Ovariectomized rats showed a 2.6-fold increased aggravation of vascular permeability by ioxaglate 4 g I/kg compared with sham-operated rats. Estradiol valerate (0.2-5.0 mg/kg) dose-dependently blocked ioxaglate-increased vascular permeability in ovariectomized rats. CONCLUSIONS. These findings suggest that climacterium is included, at least in part, in the risk factors for contrast-induced adverse pulmonary reactions, and this risk is lowered by estrogen replacement therapy.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalInvestigative Radiology
Issue number3
Publication statusPublished - Mar 24 2001
Externally publishedYes


  • Contrast media
  • Estradiol
  • Pulmonary edema
  • Rat climacterium model

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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