@inproceedings{8aad7b076e8944beaa1702189f942e18,
title = "Controlled release of a protein using a ceramic carrier and zinc ions as a novel approach to the treatment of osteoporosis",
abstract = "Injectable formulations with systemically or locally controlled release of protein drugs have been required to ameliorate their efficacy and reduce adverse effects. In this paper, the release properties of osteoprotegerin (OPG) from hydroxyapatite / chondroitin sulfate (HAp/ChS) microparticles were described. The formulation was produced by subsequent addition of zinc chloride solution into a mixture of HAp/ChS microparticles and OPG solution. The release of OPG from the formulation in PBS was positively correlated with soaking time without any initial burst release. The release rate decreased with an increased amount of zinc cations, which did not depend on ChS wt% in the microparticles. The controlled release of OPG could provide an improvement of drug delivery and a reduction of adverse effects associated with the use of antiresortive agents.",
keywords = "Chondroitin sulfate, Controlled release, Hydroxyapatite, Osteoporosis, Osteoprotegerin, Zinc",
author = "H. Watanabe and T. Ikoma and M. Tanaka and T. Yoshioka and J. Tanaka",
note = "Publisher Copyright: {\textcopyright} (2015) Trans Tech Publications, Switzerland.; 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 ; Conference date: 06-11-2014 Through 08-11-2014",
year = "2015",
doi = "10.4028/www.scientific.net.KEM.631.332",
language = "English",
series = "Key Engineering Materials",
publisher = "Trans Tech Publications Ltd",
pages = "332--337",
editor = "Maria-Pau Ginebra and Cristina Canal and Montserrat Espanol and Montufar, {Edgar B.} and Perez, {Roman A.}",
booktitle = "Bioceramics 26",
}