Coordination of Cilia Movements in Multi-Ciliated Cells

Masaki Arata, Fumiko Matsukawa Usami, Toshihiko Fujimori

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Multiple motile cilia are formed at the apical surface of multi-ciliated cells in the epithelium of the oviduct or the fallopian tube, the trachea, and the ventricle of the brain. Those cilia beat unidirectionally along the tissue axis, and this provides a driving force for directed movements of ovulated oocytes, mucus, and cerebrospinal fluid in each of these organs. Furthermore, cilia movements show temporal coordination between neighboring cilia. To establish such coordination of cilia movements, cilia need to sense and respond to various cues, including the organ’s orientation and movements of neighboring cilia. In this review, we discuss the mechanisms by which cilia movements of multi-ciliated cells are coordinated, focusing on planar cell polarity and the cytoskeleton, and highlight open questions for future research.

Original languageEnglish
Article number47
JournalJournal of Developmental Biology
Volume10
Issue number4
DOIs
Publication statusPublished - Dec 2022

Keywords

  • cytoskeleton
  • motile cilia
  • multi-ciliated cells
  • planar cell polarity

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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