Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain

Masahisa Kaneko; Koji Abe; Kyuya Kogure; Hiroshi Saito; Norio Matsuki

doi:10.1016/0304-3940(93)90735-4

Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain

Masahisa Kaneko, Koji Abe, Kyuya Kogure, Hiroshi Saito, Norio Matsuki

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.

Original language	English
Pages (from-to)	195-198
Number of pages	4
Journal	Neuroscience Letters
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(93)90735-4
Publication status	Published - Jul 23 1993
Externally published	Yes

Keywords

Diazepam
Electroconvulsive seizure
Heat shock cognate protein
Heat shock protein
Mouse
Northern blot hybridization
Phenytoin
Time course

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(93)90735-4

Cite this

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title = "Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain",

abstract = "The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.",

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T1 - Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain

AU - Kaneko, Masahisa

AU - Abe, Koji

AU - Kogure, Kyuya

AU - Saito, Hiroshi

AU - Matsuki, Norio

PY - 1993/7/23

Y1 - 1993/7/23

N2 - The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.

AB - The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain. Electrical shock induced mRNA of heat shock cognate protein (HSC70), but not heat shock protein (HSP70) mRNA. The induction was maximum 1 h after the ECS and continued for several hours, followed by long-lasting depression. Diazepam slightly prevented the ECS, but strongly attenuated the induction of HSC70 mRNA. Whereas phenytoin, which blocked the seizure, did not decrease but delayed the induction of HSC70 mRNA. The present results suggest that HSC70 mRNA level is increased with the ECS and that the induction level did not necessarily correlate the severity of the seizure.

KW - Diazepam

KW - Electroconvulsive seizure

KW - Heat shock cognate protein

KW - Heat shock protein

KW - Mouse

KW - Northern blot hybridization

KW - Phenytoin

KW - Time course

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Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain

Abstract

Keywords

ASJC Scopus subject areas

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