Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review

Keita Miyake; Takashi Hara; Etsuko Oshima; Kiyohiro Kawada; Hideki Ishizu; Yuko Yamauchi; Katsuya Satoh; Tetsuyuki Kitamoto; Shintaro Takenoshita; Seishi Terada; Norihito Yamada

doi:10.1186/s12883-018-1055-y

Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review

Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada, Norihito Yamada

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions: This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.

Original language	English
Article number	54
Journal	BMC Neurology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12883-018-1055-y
Publication status	Published - Apr 25 2018

Keywords

Alzheimer disease
Creutzfeldt-Jakob disease
Epilepsy
Seizure
Status epilepticus

ASJC Scopus subject areas

Clinical Neurology

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10.1186/s12883-018-1055-y

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Miyake, K., Hara, T., Oshima, E., Kawada, K., Ishizu, H., Yamauchi, Y., Satoh, K., Kitamoto, T., Takenoshita, S., Terada, S., & Yamada, N. (2018). Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review. BMC Neurology, 18(1), Article 54. https://doi.org/10.1186/s12883-018-1055-y

Miyake, K, Hara, T, Oshima, E, Kawada, K, Ishizu, H, Yamauchi, Y, Satoh, K, Kitamoto, T, Takenoshita, S , Terada, S & Yamada, N 2018, 'Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review', BMC Neurology, vol. 18, no. 1, 54. https://doi.org/10.1186/s12883-018-1055-y

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title = "Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review",

abstract = "Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions: This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.",

keywords = "Alzheimer disease, Creutzfeldt-Jakob disease, Epilepsy, Seizure, Status epilepticus",

author = "Keita Miyake and Takashi Hara and Etsuko Oshima and Kiyohiro Kawada and Hideki Ishizu and Yuko Yamauchi and Katsuya Satoh and Tetsuyuki Kitamoto and Shintaro Takenoshita and Seishi Terada and Norihito Yamada",

note = "Funding Information: This study is partly supported by a grant from the Zikei Institute of Psychiatry. Publisher Copyright: {\textcopyright} 2018 The Author(s).",

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doi = "10.1186/s12883-018-1055-y",

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AU - Miyake, Keita

AU - Hara, Takashi

AU - Oshima, Etsuko

AU - Kawada, Kiyohiro

AU - Ishizu, Hideki

AU - Yamauchi, Yuko

AU - Satoh, Katsuya

AU - Kitamoto, Tetsuyuki

AU - Takenoshita, Shintaro

AU - Terada, Seishi

AU - Yamada, Norihito

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N2 - Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions: This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.

AB - Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions: This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.

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KW - Creutzfeldt-Jakob disease

KW - Epilepsy

KW - Seizure

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Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review

Abstract

Keywords

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