Cross-excitation in peripheral sensory ganglia associated with pain transmission

Katsuhiro Omoto; Kotaro Maruhama; Ryuji Terayama; Yumiko Yamamoto; Osamu Matsushita; Tomosada Sugimoto; Keiji Oguma; Yoshizo Matsuka

doi:10.3390/toxins7082906

Cross-excitation in peripheral sensory ganglia associated with pain transmission

Katsuhiro Omoto, Kotaro Maruhama, Ryuji Terayama, Yumiko Yamamoto, Osamu Matsushita, Tomosada Sugimoto, Keiji Oguma, Yoshizo Matsuka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.

Original language	English
Pages (from-to)	2906-2917
Number of pages	12
Journal	Toxins
Volume	7
Issue number	8
DOIs	https://doi.org/10.3390/toxins7082906
Publication status	Published - Aug 4 2015

Keywords

Botulinum toxin
Dorsal root ganglion
Mechanical allodynia
Transmitter release

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

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10.3390/toxins7082906

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title = "Cross-excitation in peripheral sensory ganglia associated with pain transmission",

abstract = "Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.",

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author = "Katsuhiro Omoto and Kotaro Maruhama and Ryuji Terayama and Yumiko Yamamoto and Osamu Matsushita and Tomosada Sugimoto and Keiji Oguma and Yoshizo Matsuka",

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AU - Omoto, Katsuhiro

AU - Maruhama, Kotaro

AU - Terayama, Ryuji

AU - Yamamoto, Yumiko

AU - Matsushita, Osamu

AU - Sugimoto, Tomosada

AU - Oguma, Keiji

AU - Matsuka, Yoshizo

PY - 2015/8/4

Y1 - 2015/8/4

N2 - Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.

AB - Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.

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KW - Dorsal root ganglion

KW - Mechanical allodynia

KW - Transmitter release

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Cross-excitation in peripheral sensory ganglia associated with pain transmission

Abstract

Keywords

ASJC Scopus subject areas

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