Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse

Ikuo Yamamoto; Kazuhito Watanabe; Shizuo Narimatsu; Koichi Hamajima; Hidetoshi Yoshimura

doi:10.1016/0014-2999(85)90752-6

Cross-tolerance to the hypothermic effect of Δ⁸-tetrahydrocannabinol 11-hydroxy-Δ⁸-tetrahydrocannabinol and chlorpromazine in the mouse

Ikuo Yamamoto, Kazuhito Watanabe, Shizuo Narimatsu, Koichi Hamajima, Hidetoshi Yoshimura

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

When a 5 mg/kg i.v. dose of Δ⁸-tetrahydrocannabinol (Δ⁸-THC) and 11-hydroxy-Δ⁸-tetrahydrocannabinol (11-OH-Δ⁸-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ⁸-THC and 11-OH-Δ⁸-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ⁸-THC was greater than that to Δ⁸-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ⁸-THC has some role in the development of tolerance to the hypothermic effect of Δ⁸-THC in mice.

Original language	English
Pages (from-to)	159-166
Number of pages	8
Journal	European Journal of Pharmacology
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(85)90752-6
Publication status	Published - May 8 1985

Keywords

11-Hydroxy-Δ-tetrahydrocannabinol
Centrally acting drugs
Chlorpromazine
Cross-tolerance
Hypothermia
Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(85)90752-6

Cite this

@article{e82838ea31f14afe9901098ee6054d82,

title = "Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse",

abstract = "When a 5 mg/kg i.v. dose of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ8-THC and 11-OH-Δ8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ8-THC was greater than that to Δ8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ8-THC has some role in the development of tolerance to the hypothermic effect of Δ8-THC in mice.",

keywords = "11-Hydroxy-Δ-tetrahydrocannabinol, Centrally acting drugs, Chlorpromazine, Cross-tolerance, Hypothermia, Δ-Tetrahydrocannabinol",

author = "Ikuo Yamamoto and Kazuhito Watanabe and Shizuo Narimatsu and Koichi Hamajima and Hidetoshi Yoshimura",

year = "1985",

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T1 - Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse

AU - Yamamoto, Ikuo

AU - Watanabe, Kazuhito

AU - Narimatsu, Shizuo

AU - Hamajima, Koichi

AU - Yoshimura, Hidetoshi

PY - 1985/5/8

Y1 - 1985/5/8

N2 - When a 5 mg/kg i.v. dose of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ8-THC and 11-OH-Δ8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ8-THC was greater than that to Δ8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ8-THC has some role in the development of tolerance to the hypothermic effect of Δ8-THC in mice.

AB - When a 5 mg/kg i.v. dose of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ8-THC and 11-OH-Δ8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ8-THC was greater than that to Δ8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ8-THC has some role in the development of tolerance to the hypothermic effect of Δ8-THC in mice.

KW - 11-Hydroxy-Δ-tetrahydrocannabinol

KW - Centrally acting drugs

KW - Chlorpromazine

KW - Cross-tolerance

KW - Hypothermia

KW - Δ-Tetrahydrocannabinol

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