TY - JOUR
T1 - CSF flow dynamics in motor neuron disease
AU - Sato, Kota
AU - Morimoto, Nobutoshi
AU - Matsuura, Tohru
AU - Ohta, Yasuyuki
AU - Tsunoda, Masatoshi
AU - Ikeda, Yoshio
AU - Abe, Koji
PY - 2012/6
Y1 - 2012/6
N2 - Objective: To assess cerebrospinal fluid (CSF) flow dynamics involvement in the pathogenesis of amyotrophic lateral sclerosis (ALS), we conducted CSF flow studies on 40 individuals with motor neuron diseases (MNDs) including ALS, and 28 age-matched normal and disease [cervical spondylosis (CS)] controls. Methods: The CSF pulsatile velocity anterior to the cervical cord at level C5 during one heart beat was determined non-invasively by phase-contrast electrocardiography-triggered magnetic resonance imaging. Results: In MND, caudal CSF velocity peaked at 25% of the cardiac cycle after the R wave (UTc/RR), showing an increased delay in comparison to normal controls, while amplitude Hc was significantly larger than that in CS. Discussion: We conclude that CSF flow dynamics of MND differ from those of controls and may thus facilitate differentiation of MND from CS.
AB - Objective: To assess cerebrospinal fluid (CSF) flow dynamics involvement in the pathogenesis of amyotrophic lateral sclerosis (ALS), we conducted CSF flow studies on 40 individuals with motor neuron diseases (MNDs) including ALS, and 28 age-matched normal and disease [cervical spondylosis (CS)] controls. Methods: The CSF pulsatile velocity anterior to the cervical cord at level C5 during one heart beat was determined non-invasively by phase-contrast electrocardiography-triggered magnetic resonance imaging. Results: In MND, caudal CSF velocity peaked at 25% of the cardiac cycle after the R wave (UTc/RR), showing an increased delay in comparison to normal controls, while amplitude Hc was significantly larger than that in CS. Discussion: We conclude that CSF flow dynamics of MND differ from those of controls and may thus facilitate differentiation of MND from CS.
KW - Amyotrophic lateral sclerosis
KW - Cerebrospinal fluid
KW - MRI
KW - Motor neuron disease
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U2 - 10.1179/1743132812Y.0000000043
DO - 10.1179/1743132812Y.0000000043
M3 - Article
C2 - 22664138
AN - SCOPUS:84863795489
SN - 0161-6412
VL - 34
SP - 512
EP - 517
JO - Neurological Research
JF - Neurological Research
IS - 5
ER -