CT fluoroscopy-guided core needle biopsy of anterior mediastinal masses

T. Iguchi, T. Hiraki, Y. Matsui, Hiroyasu Fujiwara, J. Sakurai, Yoshihisa Masaoka, M. Uka, T. Tanaka, H. Gobara, Susumu Kanazawa

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Objective: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. Materials and methods: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [± standard deviation] age, 53.8 ± 20.0 years; range, 14–88 years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings. The biopsy results were compared with the final diagnosis, and the biopsy procedures grouped by pathologic findings into diagnostic success and failure groups. Multiple putative risk factors for diagnostic failure were then assessed. Results: Seventy-one biopsies (71 masses; mean size, 67.5 ± 27.3 mm; range 8.6–128.2 mm) were analyzed. We identified 17 grade 1 and one grade 2 adverse events (25.4% overall) according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Sixty-nine biopsies (97.2%) provided samples fit for pathologic analysis. Diagnostic failure was found for eight (11.3%) masses; the 63 masses diagnosed successfully included thymic carcinoma (n = 17), lung cancer (n = 14), thymoma (n = 12), malignant lymphoma (n = 11), germ cell tumor (n = 3), and others (n = 6). Using a thinner needle (i.e., a 20-gauge needle) was the sole significant risk factor for diagnostic failure (P = 0.039). Conclusion: CT fluoroscopy-guided biopsy of anterior mediastinal masses was safe and had a high diagnostic yield; however, using a thinner biopsy needle significantly increased the risk of a failed diagnosis.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalDiagnostic and Interventional Imaging
Issue number2
Publication statusPublished - Feb 2018


  • Biopsy
  • Fluoroscopy
  • Mediastinal tumor
  • Tomography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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