Current and Future Status of PET Myocardial Perfusion Tracers

Christoph Rischpler; Takahiro Higuchi; Stephan G. Nekolla

doi:10.1007/s12410-014-9303-z

Current and Future Status of PET Myocardial Perfusion Tracers

Christoph Rischpler, Takahiro Higuchi, Stephan G. Nekolla

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Over the last 2 decades, positron emission tomography (PET) myocardial perfusion imaging has been proven to be highly valuable for the detection and grading of coronary artery disease. Furthermore, its diagnostic accuracy seems to outperform on single photon emission computed tomographic myocardial perfusion imaging not least because of the potential of absolute quantification of myocardial blood flow. In a clinical setting, however, the use of PET is still limited. One major hampering factor is the lack of an ideal PET perfusion tracer for daily clinical routine. This article aims to review the currently available PET myocardial perfusion tracers as well as the question if those tracers that are being developed and about to be translated into clinics have the potential to overcome this issue.

Original language	English
Journal	Current Cardiovascular Imaging Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/s12410-014-9303-z
Publication status	Published - Jan 2015
Externally published	Yes

Keywords

F-flurpiridaz
Myocardial perfusion imaging
N-ammonia
O-water
PET tracers
Rubidium-82

ASJC Scopus subject areas

Histology
Applied Microbiology and Biotechnology
Cell Biology

Access to Document

10.1007/s12410-014-9303-z

Cite this

@article{c95ea3346b9949a59ae6de0f8412da04,

title = "Current and Future Status of PET Myocardial Perfusion Tracers",

abstract = "Over the last 2 decades, positron emission tomography (PET) myocardial perfusion imaging has been proven to be highly valuable for the detection and grading of coronary artery disease. Furthermore, its diagnostic accuracy seems to outperform on single photon emission computed tomographic myocardial perfusion imaging not least because of the potential of absolute quantification of myocardial blood flow. In a clinical setting, however, the use of PET is still limited. One major hampering factor is the lack of an ideal PET perfusion tracer for daily clinical routine. This article aims to review the currently available PET myocardial perfusion tracers as well as the question if those tracers that are being developed and about to be translated into clinics have the potential to overcome this issue.",

keywords = "F-flurpiridaz, Myocardial perfusion imaging, N-ammonia, O-water, PET tracers, Rubidium-82",

author = "Christoph Rischpler and Takahiro Higuchi and Nekolla, {Stephan G.}",

note = "Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

year = "2015",

month = jan,

doi = "10.1007/s12410-014-9303-z",

language = "English",

volume = "8",

journal = "Current Cardiovascular Imaging Reports",

issn = "1941-9066",

publisher = "Current Medicine Group",

number = "1",

}

TY - JOUR

T1 - Current and Future Status of PET Myocardial Perfusion Tracers

AU - Rischpler, Christoph

AU - Higuchi, Takahiro

AU - Nekolla, Stephan G.

PY - 2015/1

Y1 - 2015/1

N2 - Over the last 2 decades, positron emission tomography (PET) myocardial perfusion imaging has been proven to be highly valuable for the detection and grading of coronary artery disease. Furthermore, its diagnostic accuracy seems to outperform on single photon emission computed tomographic myocardial perfusion imaging not least because of the potential of absolute quantification of myocardial blood flow. In a clinical setting, however, the use of PET is still limited. One major hampering factor is the lack of an ideal PET perfusion tracer for daily clinical routine. This article aims to review the currently available PET myocardial perfusion tracers as well as the question if those tracers that are being developed and about to be translated into clinics have the potential to overcome this issue.

AB - Over the last 2 decades, positron emission tomography (PET) myocardial perfusion imaging has been proven to be highly valuable for the detection and grading of coronary artery disease. Furthermore, its diagnostic accuracy seems to outperform on single photon emission computed tomographic myocardial perfusion imaging not least because of the potential of absolute quantification of myocardial blood flow. In a clinical setting, however, the use of PET is still limited. One major hampering factor is the lack of an ideal PET perfusion tracer for daily clinical routine. This article aims to review the currently available PET myocardial perfusion tracers as well as the question if those tracers that are being developed and about to be translated into clinics have the potential to overcome this issue.

KW - F-flurpiridaz

KW - Myocardial perfusion imaging

KW - N-ammonia

KW - O-water

KW - PET tracers

KW - Rubidium-82

UR - http://www.scopus.com/inward/record.url?scp=84919941538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919941538&partnerID=8YFLogxK

U2 - 10.1007/s12410-014-9303-z

DO - 10.1007/s12410-014-9303-z

M3 - Review article

AN - SCOPUS:84919941538

SN - 1941-9066

VL - 8

JO - Current Cardiovascular Imaging Reports

JF - Current Cardiovascular Imaging Reports

IS - 1

ER -

Current and Future Status of PET Myocardial Perfusion Tracers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this