Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia

Fumio Otsuka; Toshio Ogura; Kazushi Nakao; Nobuhiko Hayakawa; Yukari Mimura; Takayoshi Yamauchi; Hirofumi Makino

doi:10.2169/internalmedicine.37.385

Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia

Fumio Otsuka, Toshio Ogura, Kazushi Nakao, Nobuhiko Hayakawa, Yukari Mimura, Takayoshi Yamauchi, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 49-year-old woman with Cushing's syndrome due to unilateral adrenal hyperplasia is presented. She had developed obesity and menopause for 2 years, but no hypertension or hypertrichosis was observed. Although plasma adrenocorticotropin and serum cortisol levels were within normal ranges, the circadian rhythm has completely disappeared. Free thyroxine and triiodothyronine levels were decreased. Adrenocorticotropin did not respond to corticotropinreleasing hormone, and urinary excretion of 17-hydroxycorticosteroids was not suppressed by dexamethasone. Abdominal computed tomography and ¹³¹-Adosterol scintigraphy demonstrated a unilateral functioning mass in the left adrenal gland. The resected left adrenal mass was pathologically diagnosed as the rare condition of adrenocortical nodular hyperplasia.

Original language	English
Pages (from-to)	385-390
Number of pages	6
Journal	Internal Medicine
Volume	37
Issue number	4
DOIs	https://doi.org/10.2169/internalmedicine.37.385
Publication status	Published - 1998

Keywords

Adrenalectomy
Dexamethasone suppression test
Glucocorticoid
Thyroid

ASJC Scopus subject areas

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.37.385

Cite this

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abstract = "A 49-year-old woman with Cushing's syndrome due to unilateral adrenal hyperplasia is presented. She had developed obesity and menopause for 2 years, but no hypertension or hypertrichosis was observed. Although plasma adrenocorticotropin and serum cortisol levels were within normal ranges, the circadian rhythm has completely disappeared. Free thyroxine and triiodothyronine levels were decreased. Adrenocorticotropin did not respond to corticotropinreleasing hormone, and urinary excretion of 17-hydroxycorticosteroids was not suppressed by dexamethasone. Abdominal computed tomography and 131-Adosterol scintigraphy demonstrated a unilateral functioning mass in the left adrenal gland. The resected left adrenal mass was pathologically diagnosed as the rare condition of adrenocortical nodular hyperplasia.",

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T1 - Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia

AU - Otsuka, Fumio

AU - Ogura, Toshio

AU - Nakao, Kazushi

AU - Hayakawa, Nobuhiko

AU - Mimura, Yukari

AU - Yamauchi, Takayoshi

AU - Makino, Hirofumi

PY - 1998

Y1 - 1998

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AB - A 49-year-old woman with Cushing's syndrome due to unilateral adrenal hyperplasia is presented. She had developed obesity and menopause for 2 years, but no hypertension or hypertrichosis was observed. Although plasma adrenocorticotropin and serum cortisol levels were within normal ranges, the circadian rhythm has completely disappeared. Free thyroxine and triiodothyronine levels were decreased. Adrenocorticotropin did not respond to corticotropinreleasing hormone, and urinary excretion of 17-hydroxycorticosteroids was not suppressed by dexamethasone. Abdominal computed tomography and 131-Adosterol scintigraphy demonstrated a unilateral functioning mass in the left adrenal gland. The resected left adrenal mass was pathologically diagnosed as the rare condition of adrenocortical nodular hyperplasia.

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KW - Dexamethasone suppression test

KW - Glucocorticoid

KW - Thyroid

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Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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