Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: A clinical overview

Keiji Iwatsuki, Zigang Xu, Mikio Ohtsuka, Fumio Kaneko

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)181-195
Number of pages15
JournalJournal of dermatological science
Issue number3
Publication statusPublished - Apr 2000


  • Cutaneous lymphoproliferative disorders
  • Epstein-Barr virus
  • Hydroa vacciniforme
  • Infectious mononucleosis
  • NK cell lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


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