Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of the Ceramic Society of Japan
Issue number1325
Publication statusPublished - Jan 2006


  • Cytocompatibility
  • Emulsion polymerization
  • Grafting
  • Silicone
  • Surface modification
  • γ-methacryloxypropyltri-methoxysilane

ASJC Scopus subject areas

  • Ceramics and Composites
  • General Chemistry
  • Condensed Matter Physics
  • Materials Chemistry


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