Cytocompatible and antibacterial properties of chitosan-siloxane hybrid spheres

Yuki Shirosaki, Manato Nakatsukasa, Saki Yasutomi, Susana Cruz-Neves, Satoshi Hayakawa, Akiyoshi Osaka, Toshinari Maeda, Toshiki Miyazaki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Microporous spheres in a hybrid system consisting of chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) have advantages in a range of applications, e.g., as vehicles for cell transplantation and soft tissue defect filling materials, because of their excellent cytocompatibility with various cells. In this study, microporous chitosan-GPTMS spheres were prepared by dropping chitosan-GPTMS precursor sols,with orwithout a ceriumchloride, into liquid nitrogen using a syringe pump. The droplets were then freeze dried to give the pores of size 10 to 50 μm. The cell culture tests showed that L929 fibroblast-like cells migrated into the micropores larger than 50 μm in diameter, whereasMG63 osteoblast-like cells proliferated well and covered the granule surfaces. The spheres with cerium chloride showed antibacterial properties against both gram-negative and gram-positive bacteria.

Original languageEnglish
Article number1676
Issue number10
Publication statusPublished - Oct 1 2019


  • Antibacterial property
  • Cell behavior
  • Cerium ion
  • Chitosan-siloxane hybrid
  • Microporous spheres

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics


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