D2 dopamine receptor alleles influence prognosis of methamphetamine psychosis

H. Ujike, K. Nakata, M. Takaki, T. Inada, M. Harano, M. Yamada, N. Ozaki

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1 Citation (Scopus)


The present study was done by JGIDA (Japanese Genetic Initiative for Drug Abuse), consisting of above authors and A. Sakai, H. T. Komiyama, Mitsushio, Y. Sekine, T. Maeda, S. Iwashita, I. Sora and M. Iyo. Previous studies indicated that polymorphisms of D2 dopamine receptor showed a possible association with alcoholism, pathological gambling, smoking and several personality traits. We examined association study between the patients with methamphetamine psychosis and TaqI A alleles of DRD2. Subjects were 115 methamphetamine users and age- and sex-matched 112 controls. All were Japanese. There was no significant difference in genotypic and allelic distribution of TaqI A between all methamphetamine users and controls. However, the patients with prolonged methamphetamine psychosis (lasting more than 1 month after therapy) showed a significant excess A2 positive genotype (p + ADO-0.0098) than those with transient psychosis (psychotic symptoms disappeared within 1 month after therapy). The patients with flashback also showed a significant excess A2 positive genotype than those without flashback (p + ADO-0.0049). A2 allele of TaqI polymorphism of DRD2 may confer prolongation of psychotic phase and liability to flashback.

Original languageEnglish
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Issue number7
Publication statusPublished - Oct 8 2001

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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