TY - JOUR
T1 - De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland
T2 - A case report
AU - Santos, Karina Cecília Panelli
AU - Matsuzaki, Hidenobu
AU - Unetsubo, Teruhisa
AU - Tsuyoshi, Shimo
AU - Nagatsuka, Hitoshi
AU - Asaumi, Jun Ichi
N1 - Publisher Copyright:
© 2017, Spandidos Publications. All rights reserved.
PY - 2017/4
Y1 - 2017/4
N2 - Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.
AB - Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.
KW - Dynamic magnetic resonance imaging
KW - Myoepithelial carcinoma
KW - Submandibular glands
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U2 - 10.3892/ol.2017.5783
DO - 10.3892/ol.2017.5783
M3 - Article
AN - SCOPUS:85015289642
SN - 1792-1074
VL - 13
SP - 2679
EP - 2683
JO - Oncology Letters
JF - Oncology Letters
IS - 4
ER -
