Defining early mycosis fungoides

Nicola Pimpinelli, Elise A. Olsen, Marco Santucci, Eric Vonderheid, Andreas C. Haeffner, Seth Stevens, Guenter Burg, Lorenzo Cerroni, Brigitte Dreno, Earl Glusac, Joan Guitart, Peter W. Heald, Werner Kempf, Robert Knobler, Stuart Lessin, Christian Sander, Bruce S. Smoller, Gladys Telang, Sean Whittaker, Keiji IwatsukiErik Obitz, Masahiro Takigawa, Maria L. Turner, Gary S. Wood

Research output: Contribution to journalArticlepeer-review

418 Citations (Scopus)


This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.

Original languageEnglish
Pages (from-to)1053-1063
Number of pages11
JournalJournal of the American Academy of Dermatology
Issue number6
Publication statusPublished - Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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