Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists

Kenji Kishida; Atsushi Aoyama; Yuichi Hashimoto; Hiroyuki Miyachi

doi:10.1248/cpb.58.1525

Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists

Kenji Kishida, Atsushi Aoyama, Yuichi Hashimoto, Hiroyuki Miyachi

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

Original language	English
Pages (from-to)	1524-1528
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	58
Issue number	11
DOIs	https://doi.org/10.1248/cpb.58.1525
Publication status	Published - Nov 2010

Keywords

Fluorescent ligand
Liver X receptor
Liver X receptor antagonist

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.58.1525

Cite this

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title = "Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists",

abstract = "Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.",

keywords = "Fluorescent ligand, Liver X receptor, Liver X receptor antagonist",

author = "Kenji Kishida and Atsushi Aoyama and Yuichi Hashimoto and Hiroyuki Miyachi",

year = "2010",

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language = "English",

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AU - Kishida, Kenji

AU - Aoyama, Atsushi

AU - Hashimoto, Yuichi

AU - Miyachi, Hiroyuki

PY - 2010/11

Y1 - 2010/11

N2 - Based on our structure-activity relationship study of liver X receptor (LXR) ligands, we designed and synthesized fluorescent LXR antagonists containing an unsubstituted or substituted amino group on a phthalimide unit.

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KW - Fluorescent ligand

KW - Liver X receptor

KW - Liver X receptor antagonist

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AN - SCOPUS:78049459888

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EP - 1528

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 11

ER -

Design and synthesis of phthalimide-based fluorescent liver X receptor antagonists

Abstract

Keywords

ASJC Scopus subject areas

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