Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

Shinichiro Kamino; Hayato Ichikawa; Shun ichi Wada; Yuka Horio; Yoshihide Usami; Takako Yamaguchi; Toshiki Koda; Aki Harada; Kazusa Shimanuki; Masao Arimoto; Mitsunobu Doi; Yoshikazu Fujita

doi:10.1016/j.bmcl.2008.06.065

Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

Shinichiro Kamino, Hayato Ichikawa, Shun ichi Wada, Yuka Horio, Yoshihide Usami, Takako Yamaguchi, Toshiki Koda, Aki Harada, Kazusa Shimanuki, Masao Arimoto, Mitsunobu Doi, Yoshikazu Fujita

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy.

Original language	English
Pages (from-to)	4380-4384
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2008.06.065
Publication status	Published - Aug 1 2008

Keywords

Chemical biology
Photochemical properties
Regioisomerically pure
Unsymmetrical xanthene derivatives

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.06.065

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Kamino, S., Ichikawa, H., Wada, S. I., Horio, Y., Usami, Y., Yamaguchi, T., Koda, T., Harada, A., Shimanuki, K., Arimoto, M., Doi, M., & Fujita, Y. (2008). Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties. Bioorganic and Medicinal Chemistry Letters, 18(15), 4380-4384. https://doi.org/10.1016/j.bmcl.2008.06.065

Kamino, S, Ichikawa, H, Wada, SI, Horio, Y, Usami, Y, Yamaguchi, T, Koda, T, Harada, A, Shimanuki, K, Arimoto, M, Doi, M & Fujita, Y 2008, 'Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 15, pp. 4380-4384. https://doi.org/10.1016/j.bmcl.2008.06.065

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AU - Kamino, Shinichiro

AU - Ichikawa, Hayato

AU - Wada, Shun ichi

AU - Horio, Yuka

AU - Usami, Yoshihide

AU - Yamaguchi, Takako

AU - Koda, Toshiki

AU - Harada, Aki

AU - Shimanuki, Kazusa

AU - Arimoto, Masao

AU - Doi, Mitsunobu

AU - Fujita, Yoshikazu

PY - 2008/8/1

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AB - We have demonstrated the synthesis of regioisomerically pure unsymmetrical xanthene derivatives consisting of three units which can be independently modified to control their physical properties. The photochemical properties of the synthetic unsymmetrical xanthene derivatives were investigated in solution by UV-vis absorption and fluorescence measurements, and their cell imaging properties were examined by confocal laser-scanning microscopy.

KW - Chemical biology

KW - Photochemical properties

KW - Regioisomerically pure

KW - Unsymmetrical xanthene derivatives

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Design and synthesis of regioisomerically pure unsymmetrical xanthene derivatives for staining live cells and their photochemical properties

Abstract

Keywords

ASJC Scopus subject areas

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