Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

Subhra Mandal; Gerald J. Bakeine; Silke Krol; Cinzia Ferrari; Anna M. Clerici; Cecilia Zonta; Laura Cansolino; Francesca Ballarini; Silva Bortolussi; Subrina Stella; Nicoletta Protti; Piero Bruschi; Saverio Altieri

doi:10.1016/j.apradiso.2011.05.002

Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

Subhra Mandal, Gerald J. Bakeine, Silke Krol, Cinzia Ferrari, Anna M. Clerici, Cecilia Zonta, Laura Cansolino, Francesca Ballarini, Silva Bortolussi, Subrina Stella, Nicoletta Protti, Piero Bruschi, Saverio Altieri

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors.

Original language	English
Pages (from-to)	1692-1697
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2011.05.002
Publication status	Published - Dec 2011
Externally published	Yes

Keywords

Biocompatibility
BNCT
Folate receptor
Functionalized gold nanoparticles
Optical molecular imaging
Targeted boron delivery

ASJC Scopus subject areas

Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apradiso.2011.05.002

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Mandal, S., Bakeine, G. J., Krol, S., Ferrari, C., Clerici, A. M., Zonta, C., Cansolino, L., Ballarini, F., Bortolussi, S., Stella, S., Protti, N., Bruschi, P., & Altieri, S. (2011). Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications. Applied Radiation and Isotopes, 69(12), 1692-1697. https://doi.org/10.1016/j.apradiso.2011.05.002

Mandal, S, Bakeine, GJ, Krol, S, Ferrari, C, Clerici, AM, Zonta, C, Cansolino, L, Ballarini, F, Bortolussi, S, Stella, S, Protti, N, Bruschi, P & Altieri, S 2011, 'Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications', Applied Radiation and Isotopes, vol. 69, no. 12, pp. 1692-1697. https://doi.org/10.1016/j.apradiso.2011.05.002

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AU - Mandal, Subhra

AU - Bakeine, Gerald J.

AU - Krol, Silke

AU - Ferrari, Cinzia

AU - Clerici, Anna M.

AU - Zonta, Cecilia

AU - Cansolino, Laura

AU - Ballarini, Francesca

AU - Bortolussi, Silva

AU - Stella, Subrina

AU - Protti, Nicoletta

AU - Bruschi, Piero

AU - Altieri, Saverio

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KW - Biocompatibility

KW - BNCT

KW - Folate receptor

KW - Functionalized gold nanoparticles

KW - Optical molecular imaging

KW - Targeted boron delivery

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Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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