Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide

Makoto Muranaka, Hidekazu Yoshizawa, Tsutomu Ono

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Poly(D,L-lactide) (PDLLA) microspheres with narrow diameter distribution were prepared by dispersion polymerization of D,L-lactide in xylene/ heptane (1:2, v/v) using poly(dodecyl methacrylate)-g-poly(D,L-lactide) (PDMA-g-PDLLA) as a dispersion stabilizer. The particle diameters of PDLLA microspheres were controlled from 200 nm to 5 μm by altering the concentration and the graft chain number of PDMA-g-PDLLA. The effect of the copolymer composition on the particle diameter was investigated to clarify an important factor of the copolymer structure for the control of the particle diameter. As a result, it was necessary for anchor block in diblock copolymer as a dispersion stabilizer to have low solubility in the solution rather than the compatibility with particles. Moreover, we confirmed by dynamic light scattering measurement that PDMA-g-PDLLA formed micelles in the solution. In conclusion, it was clarified that PDLLA microspheres with a wide range of particle diameter were prepared due to the different kinetic stability of micelles.

Original languageEnglish
Pages (from-to)525-532
Number of pages8
JournalColloid and Polymer Science
Issue number5
Publication statusPublished - Jan 23 2009


  • Copolymeric micelles
  • Dispersion polymerization
  • Graft copolymeric stabilizer
  • Microsphere
  • Poly(D, L-lactide)

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry


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