TY - JOUR
T1 - Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators
T2 - Novel human PPARα-selective activators
AU - Miyachi, Hiroyuki
AU - Nomura, Masahiro
AU - Tanase, Takahiro
AU - Takahashi, Yukie
AU - Ide, Tomohiro
AU - Tsunoda, Masaki
AU - Murakami, Koji
AU - Awano, Katsuya
PY - 2002/1/7
Y1 - 2002/1/7
N2 - A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
AB - A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the α-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.
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U2 - 10.1016/S0960-894X(01)00672-2
DO - 10.1016/S0960-894X(01)00672-2
M3 - Article
C2 - 11738577
AN - SCOPUS:0037033187
SN - 0960-894X
VL - 12
SP - 77
EP - 80
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 1
ER -