TY - JOUR
T1 - Detecting spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography
AU - Fukui, Yusuke
AU - Hishikawa, Nozomi
AU - Sato, Kota
AU - Nakano, Yumiko
AU - Morihara, Ryuta
AU - Shang, Jingwei
AU - Takemoto, Mami
AU - Ohta, Yasuyuki
AU - Yamashita, Toru
AU - Abe, Koji
N1 - Funding Information:
This work was partly supported by Grants-in-Aid for Scientific Research (B, 25293202), (C, 15K09316) and Challenging Research ( 15K15527 ) and Young Research ( 15K21181 ), and by Grants-in-Aid from the Research Committees (Mizusawa H, Nakashima K, Nishizawa M, Sasaki H, and Aoki M) from the Ministry of Health, Labour and Welfare of Japan.
Publisher Copyright:
© 2017 Elsevier Ireland Ltd and Japan Neuroscience Society
PY - 2018/8
Y1 - 2018/8
N2 - The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5. The fractional anisotropy (FA) values of ALS-total and ALS-limb patients were significantly reduced compared with normal controls, and SBMA patients. On the other hand, the mean diffusivity (MD) values were not significantly different among normal controls and the three disease groups. The rate of disease progression (ΔFRS-R) of ALS patients was significantly correlated with FA values and central motor conduction time (CMCT). In conclusion, the present study demonstrated a significant reduction of FA values in ALS patients, and the ΔFRS-R of ALS patients showed distinct regressions with FA values and CMCT, suggesting that this DTT analysis could be useful for detecting disease progression of ALS patients.
AB - The objective of this study was to determine alteration of corticospinal tract in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor tractograhy (DTT) focusing on the cervical spinal cord (C5) and transcranial magnetic stimulation (TMS). We recruited 38 ALS, 6 spinal and bulbar muscular atrophy (SBMA), 7 spastic paraplegia (SP) patients, and 8 age-matched normal controls, and then ALS were divided into two subgroups according to their clinical type: 28 ALS-limb and 10 ALS-bulbar. DTT was performed using the diffusion tensor image (DTI) track module to reconstruct two fiber tracts via C5. The fractional anisotropy (FA) values of ALS-total and ALS-limb patients were significantly reduced compared with normal controls, and SBMA patients. On the other hand, the mean diffusivity (MD) values were not significantly different among normal controls and the three disease groups. The rate of disease progression (ΔFRS-R) of ALS patients was significantly correlated with FA values and central motor conduction time (CMCT). In conclusion, the present study demonstrated a significant reduction of FA values in ALS patients, and the ΔFRS-R of ALS patients showed distinct regressions with FA values and CMCT, suggesting that this DTT analysis could be useful for detecting disease progression of ALS patients.
KW - Amyotrophic lateral sclerosis
KW - Corticospinal tract
KW - Diffusion tensor imaging
KW - Motor evoked potentials
KW - Motor neuron disease
KW - Tractography
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U2 - 10.1016/j.neures.2017.11.005
DO - 10.1016/j.neures.2017.11.005
M3 - Article
C2 - 29174922
AN - SCOPUS:85036542827
SN - 0168-0102
VL - 133
SP - 58
EP - 63
JO - Neuroscience Research
JF - Neuroscience Research
ER -