Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia

Jesca Nakayima; Kyoko Hayashida; Ryo Nakao; Akihiro Ishii; Hirohito Ogawa; Ichiro Nakamura; Ladslav Moonga; Bernard M. Hang'ombe; Aaron S. Mweene; Yuka Thomas; Yasuko Orba; Hirofumi Sawa; Chihiro Sugimoto

doi:10.1186/s13071-014-0490-x

Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia

Jesca Nakayima, Kyoko Hayashida, Ryo Nakao, Akihiro Ishii, Hirohito Ogawa, Ichiro Nakamura, Ladslav Moonga, Bernard M. Hang'ombe, Aaron S. Mweene, Yuka Thomas, Yasuko Orba, Hirofumi Sawa, Chihiro Sugimoto

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

BACKGROUND: Wildlife may harbor infectious pathogens that are of zoonotic concern acting as a reservoir of diseases transmissible to humans and domestic animals. This is due to human-wildlife conflicts that have become more frequent and severe over recent decades, competition for the available natural habitats and resources leading to increased human encroachment on previously wild and uninhabited areas.

METHODS: A total of 88 spleen DNA samples from baboons and vervet monkeys from Zambia were tested for zoonotic pathogens using genus or species-specific PCR. The amplified products were then subjected to sequencing analysis.

RESULTS: We detected three different pathogenic agents, including Anaplasma phagocytophilum in 12 samples (13.6%), Rickettsia spp. in 35 samples (39.8%) and Babesia spp. in 2 samples (2.3%).

CONCLUSION: The continuously increasing contacts between humans and primate populations raise concerns about transmission of pathogens between these groups. Therefore, increased medical and public awareness and public health surveillance support will be required to detect and control infections caused by these agents at the interface between humans and wildlife.

Original language	English
Pages (from-to)	490
Number of pages	1
Journal	Parasites & vectors
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/s13071-014-0490-x
Publication status	Published - 2014
Externally published	Yes

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title = "Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia",

abstract = "BACKGROUND: Wildlife may harbor infectious pathogens that are of zoonotic concern acting as a reservoir of diseases transmissible to humans and domestic animals. This is due to human-wildlife conflicts that have become more frequent and severe over recent decades, competition for the available natural habitats and resources leading to increased human encroachment on previously wild and uninhabited areas.METHODS: A total of 88 spleen DNA samples from baboons and vervet monkeys from Zambia were tested for zoonotic pathogens using genus or species-specific PCR. The amplified products were then subjected to sequencing analysis.RESULTS: We detected three different pathogenic agents, including Anaplasma phagocytophilum in 12 samples (13.6%), Rickettsia spp. in 35 samples (39.8%) and Babesia spp. in 2 samples (2.3%).CONCLUSION: The continuously increasing contacts between humans and primate populations raise concerns about transmission of pathogens between these groups. Therefore, increased medical and public awareness and public health surveillance support will be required to detect and control infections caused by these agents at the interface between humans and wildlife.",

author = "Jesca Nakayima and Kyoko Hayashida and Ryo Nakao and Akihiro Ishii and Hirohito Ogawa and Ichiro Nakamura and Ladslav Moonga and Hang'ombe, {Bernard M.} and Mweene, {Aaron S.} and Yuka Thomas and Yasuko Orba and Hirofumi Sawa and Chihiro Sugimoto",

year = "2014",

doi = "10.1186/s13071-014-0490-x",

language = "English",

volume = "7",

pages = "490",

journal = "Parasites & vectors",

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T1 - Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia

AU - Nakayima, Jesca

AU - Hayashida, Kyoko

AU - Nakao, Ryo

AU - Ishii, Akihiro

AU - Ogawa, Hirohito

AU - Nakamura, Ichiro

AU - Moonga, Ladslav

AU - Hang'ombe, Bernard M.

AU - Mweene, Aaron S.

AU - Thomas, Yuka

AU - Orba, Yasuko

AU - Sawa, Hirofumi

AU - Sugimoto, Chihiro

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Wildlife may harbor infectious pathogens that are of zoonotic concern acting as a reservoir of diseases transmissible to humans and domestic animals. This is due to human-wildlife conflicts that have become more frequent and severe over recent decades, competition for the available natural habitats and resources leading to increased human encroachment on previously wild and uninhabited areas.METHODS: A total of 88 spleen DNA samples from baboons and vervet monkeys from Zambia were tested for zoonotic pathogens using genus or species-specific PCR. The amplified products were then subjected to sequencing analysis.RESULTS: We detected three different pathogenic agents, including Anaplasma phagocytophilum in 12 samples (13.6%), Rickettsia spp. in 35 samples (39.8%) and Babesia spp. in 2 samples (2.3%).CONCLUSION: The continuously increasing contacts between humans and primate populations raise concerns about transmission of pathogens between these groups. Therefore, increased medical and public awareness and public health surveillance support will be required to detect and control infections caused by these agents at the interface between humans and wildlife.

AB - BACKGROUND: Wildlife may harbor infectious pathogens that are of zoonotic concern acting as a reservoir of diseases transmissible to humans and domestic animals. This is due to human-wildlife conflicts that have become more frequent and severe over recent decades, competition for the available natural habitats and resources leading to increased human encroachment on previously wild and uninhabited areas.METHODS: A total of 88 spleen DNA samples from baboons and vervet monkeys from Zambia were tested for zoonotic pathogens using genus or species-specific PCR. The amplified products were then subjected to sequencing analysis.RESULTS: We detected three different pathogenic agents, including Anaplasma phagocytophilum in 12 samples (13.6%), Rickettsia spp. in 35 samples (39.8%) and Babesia spp. in 2 samples (2.3%).CONCLUSION: The continuously increasing contacts between humans and primate populations raise concerns about transmission of pathogens between these groups. Therefore, increased medical and public awareness and public health surveillance support will be required to detect and control infections caused by these agents at the interface between humans and wildlife.

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Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia

Abstract

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