Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

Keita Kobayashi; Kenji Yokota; Tadashi Yoshino; Yoshiro Kawahara; Ashoka Dey; Yoshikazu Hirai; Keiji Oguma; Tadaatsu Akagi

doi:10.1136/jcp.51.5.396

Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

Keita Kobayashi, Kenji Yokota, Tadashi Yoshino, Yoshiro Kawahara, Ashoka Dey, Yoshikazu Hirai, Keiji Oguma, Tadaatsu Akagi

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

Original language	English
Pages (from-to)	396-398
Number of pages	3
Journal	Journal of Clinical Pathology
Volume	51
Issue number	5
DOIs	https://doi.org/10.1136/jcp.51.5.396
Publication status	Published - 1998

Keywords

Helicobacter pylori
Immunohistochemistry
MALT lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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Kobayashi, K., Yokota, K., Yoshino, T., Kawahara, Y., Dey, A., Hirai, Y., Oguma, K., & Akagi, T. (1998). Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT). Journal of Clinical Pathology, 51(5), 396-398. https://doi.org/10.1136/jcp.51.5.396

Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT). / Kobayashi, Keita; Yokota, Kenji; Yoshino, Tadashi et al.
In: Journal of Clinical Pathology, Vol. 51, No. 5, 1998, p. 396-398.

Research output: Contribution to journal › Article › peer-review

Kobayashi, K, Yokota, K, Yoshino, T, Kawahara, Y, Dey, A, Hirai, Y, Oguma, K & Akagi, T 1998, 'Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)', Journal of Clinical Pathology, vol. 51, no. 5, pp. 396-398. https://doi.org/10.1136/jcp.51.5.396

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abstract = "Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.",

keywords = "Helicobacter pylori, Immunohistochemistry, MALT lymphoma",

author = "Keita Kobayashi and Kenji Yokota and Tadashi Yoshino and Yoshiro Kawahara and Ashoka Dey and Yoshikazu Hirai and Keiji Oguma and Tadaatsu Akagi",

year = "1998",

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AU - Kobayashi, Keita

AU - Yokota, Kenji

AU - Yoshino, Tadashi

AU - Kawahara, Yoshiro

AU - Dey, Ashoka

AU - Hirai, Yoshikazu

AU - Oguma, Keiji

AU - Akagi, Tadaatsu

PY - 1998

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N2 - Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

AB - Aims - To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. Methods - Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). Results - Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. Conclusions - Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.

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KW - Immunohistochemistry

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Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT)

Abstract

Keywords

ASJC Scopus subject areas

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