Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft

T. Pinelli; S. Altieri; F. Fossati; A. Zonta; U. Prati; L. Roveda; R. Nano

doi:10.1117/12.267875

Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft

T. Pinelli, S. Altieri, F. Fossati, A. Zonta, U. Prati, L. Roveda, R. Nano

Research output: Contribution to journal › Conference article › peer-review

Abstract

We present results on surgical technique, neutron field and irradiation facility concerning the original treatment of the liver diffused metastases. Our method plans to irradiate the isolated organ at a thermal neutron field soon after having been explanted and boron enriched and before being grafted into the same donor (liver autograft with boron neutron capture therapy). In particular the crucial point of boron uptake was investigated by a rat model with a relevant number of procedure (65). We give for the first time statistically significant results on the selective boron absorption by tumour tissues. The data reported in section 6 evidence an important progress on the way of the clinical application of the procedure.

Original language	English
Pages (from-to)	92-96
Number of pages	5
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2867
DOIs	https://doi.org/10.1117/12.267875
Publication status	Published - Feb 27 1996
Externally published	Yes
Event	International Conference Neutrons in Research and Industry 1996 - Crete, Greece Duration: Jun 9 1996 → Jun 15 1996

Keywords

Autograft
Boron uptake
Liver metastases
Neutron capture therapy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.267875

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title = "Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft",

abstract = "We present results on surgical technique, neutron field and irradiation facility concerning the original treatment of the liver diffused metastases. Our method plans to irradiate the isolated organ at a thermal neutron field soon after having been explanted and boron enriched and before being grafted into the same donor (liver autograft with boron neutron capture therapy). In particular the crucial point of boron uptake was investigated by a rat model with a relevant number of procedure (65). We give for the first time statistically significant results on the selective boron absorption by tumour tissues. The data reported in section 6 evidence an important progress on the way of the clinical application of the procedure.",

keywords = "Autograft, Boron uptake, Liver metastases, Neutron capture therapy",

author = "T. Pinelli and S. Altieri and F. Fossati and A. Zonta and U. Prati and L. Roveda and R. Nano",

note = "Funding Information: Taormina project is supported by I.N.F.N. since 1988. Support is also given by CNR (ACRO project) and IRCCS Policlinic S. Matteo, Pavia, Italy. A.N.I.S.N. and MCNP4A codes have been obtained from N.E.A. Data Bank, Paris. Funding Information: Very gratefully we acknowledge the precious collaboration of LENA laboratory for reactor operation. Prof. R. Borio, University of Perugia, gave a precious support in gamma dose measures by TLD. Taormina project is supported by I.N.F.N. since 1988. Support is also given by CNR (ACRO project) and IRCCS Policlinic S. Matteo, Pavia, Italy. A.N.I.S.N. and MCNP4A codes have been obtained from N.E.A. Data Bank, Paris. Publisher Copyright: {\textcopyright} SPIE.; International Conference Neutrons in Research and Industry 1996 ; Conference date: 09-06-1996 Through 15-06-1996",

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T1 - Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft

AU - Pinelli, T.

AU - Altieri, S.

AU - Fossati, F.

AU - Zonta, A.

AU - Prati, U.

AU - Roveda, L.

AU - Nano, R.

N1 - Funding Information: Taormina project is supported by I.N.F.N. since 1988. Support is also given by CNR (ACRO project) and IRCCS Policlinic S. Matteo, Pavia, Italy. A.N.I.S.N. and MCNP4A codes have been obtained from N.E.A. Data Bank, Paris. Funding Information: Very gratefully we acknowledge the precious collaboration of LENA laboratory for reactor operation. Prof. R. Borio, University of Perugia, gave a precious support in gamma dose measures by TLD. Taormina project is supported by I.N.F.N. since 1988. Support is also given by CNR (ACRO project) and IRCCS Policlinic S. Matteo, Pavia, Italy. A.N.I.S.N. and MCNP4A codes have been obtained from N.E.A. Data Bank, Paris. Publisher Copyright: © SPIE.

PY - 1996/2/27

Y1 - 1996/2/27

N2 - We present results on surgical technique, neutron field and irradiation facility concerning the original treatment of the liver diffused metastases. Our method plans to irradiate the isolated organ at a thermal neutron field soon after having been explanted and boron enriched and before being grafted into the same donor (liver autograft with boron neutron capture therapy). In particular the crucial point of boron uptake was investigated by a rat model with a relevant number of procedure (65). We give for the first time statistically significant results on the selective boron absorption by tumour tissues. The data reported in section 6 evidence an important progress on the way of the clinical application of the procedure.

AB - We present results on surgical technique, neutron field and irradiation facility concerning the original treatment of the liver diffused metastases. Our method plans to irradiate the isolated organ at a thermal neutron field soon after having been explanted and boron enriched and before being grafted into the same donor (liver autograft with boron neutron capture therapy). In particular the crucial point of boron uptake was investigated by a rat model with a relevant number of procedure (65). We give for the first time statistically significant results on the selective boron absorption by tumour tissues. The data reported in section 6 evidence an important progress on the way of the clinical application of the procedure.

KW - Autograft

KW - Boron uptake

KW - Liver metastases

KW - Neutron capture therapy

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JO - Proceedings of SPIE - The International Society for Optical Engineering

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Development of a method to extend, by boron neutron capture process, the therapeutic possibilities of the liver autograft

Abstract

Keywords

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