TY - JOUR
T1 - Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance
AU - Wang, Heng
AU - Shi, Zhongyan
AU - Sun, Weiqian
AU - Zhang, Jianxu
AU - Wang, Jing
AU - Shi, Yue
AU - Yang, Ruoshui
AU - Li, Chunlin
AU - Chen, Duanduan
AU - Wu, Jinglong
AU - Gongyao, Guo
AU - Xu, Yifei
N1 - Funding Information:
This work was supported by the National Key Research and Development Program of China under grant 2018YFC0115400, the National Natural Science Foundation of China (Grant Nos. 61727807, 81970404, and 81771909), the Beijing Municipal Science and Technology Commission (Z191100010618004), and the Beijing Nova Program (Z181100006218008). This work was also supported by JSPS KAKENHI Grant Numbers 18K18835, 18H01411, and 19KK0099.
Publisher Copyright:
© Copyright © 2020 Wang, Shi, Sun, Zhang, Wang, Shi, Yang, Li, Chen, Wu, Gongyao and Xu.
PY - 2020/12/8
Y1 - 2020/12/8
N2 - Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative diseases. The device and auxiliary software constitute a non-invasive neuromodulation system. The technical problems related to the multichannel high-precision output of the device were solved by an analog phase accumulator and a special driving circuit to reduce crosstalk. The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness. Finite element simulation and phantom measurements were performed to find the functional relations among the target coordinates, current ratio, and electrode position in the simplified model. Then, an appropriate approach was proposed to find electrode configurations for desired target locations in a detailed and realistic mouse model. A mouse validation experiment was carried out under the guidance of a simulation, and the reliability and positioning accuracy of temporally interfering electric stimulators were verified. Stimulator improvement and precision positioning solutions promise opportunities for further studies of temporally interfering electrical stimulation.
AB - Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative diseases. The device and auxiliary software constitute a non-invasive neuromodulation system. The technical problems related to the multichannel high-precision output of the device were solved by an analog phase accumulator and a special driving circuit to reduce crosstalk. The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness. Finite element simulation and phantom measurements were performed to find the functional relations among the target coordinates, current ratio, and electrode position in the simplified model. Then, an appropriate approach was proposed to find electrode configurations for desired target locations in a detailed and realistic mouse model. A mouse validation experiment was carried out under the guidance of a simulation, and the reliability and positioning accuracy of temporally interfering electric stimulators were verified. Stimulator improvement and precision positioning solutions promise opportunities for further studies of temporally interfering electrical stimulation.
KW - electrical stimulation
KW - finite element method
KW - mouse
KW - simulation
KW - temporally interfering
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U2 - 10.3389/fninf.2020.574189
DO - 10.3389/fninf.2020.574189
M3 - Article
AN - SCOPUS:85098077707
SN - 1662-5196
VL - 14
JO - Frontiers in Neuroinformatics
JF - Frontiers in Neuroinformatics
M1 - 574189
ER -