Development of a novel inducer of protein-protein interactions based on aplyronine A

Takayuki Ohyoshi; Atsuhiro Takano; Mayu Namiki; Tomotaka Ogura; Yuto Miyazaki; Yuta Ebihara; Koichi Takeno; Ichiro Hayakawa; Hideo Kigoshi

doi:10.1039/c8cc04613a

Development of a novel inducer of protein-protein interactions based on aplyronine A

Takayuki Ohyoshi, Atsuhiro Takano, Mayu Namiki, Tomotaka Ogura, Yuto Miyazaki, Yuta Ebihara, Koichi Takeno, Ichiro Hayakawa, Hideo Kigoshi

School of Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

Original language	English
Pages (from-to)	9537-9540
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	68
DOIs	https://doi.org/10.1039/c8cc04613a
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc04613a

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title = "Development of a novel inducer of protein-protein interactions based on aplyronine A",

abstract = "An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.",

author = "Takayuki Ohyoshi and Atsuhiro Takano and Mayu Namiki and Tomotaka Ogura and Yuto Miyazaki and Yuta Ebihara and Koichi Takeno and Ichiro Hayakawa and Hideo Kigoshi",

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doi = "10.1039/c8cc04613a",

language = "English",

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T1 - Development of a novel inducer of protein-protein interactions based on aplyronine A

AU - Ohyoshi, Takayuki

AU - Takano, Atsuhiro

AU - Namiki, Mayu

AU - Ogura, Tomotaka

AU - Miyazaki, Yuto

AU - Ebihara, Yuta

AU - Takeno, Koichi

AU - Hayakawa, Ichiro

AU - Kigoshi, Hideo

PY - 2018

Y1 - 2018

N2 - An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

AB - An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.

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DO - 10.1039/c8cc04613a

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VL - 54

SP - 9537

EP - 9540

JO - Chemical Communications

JF - Chemical Communications

IS - 68

ER -

Development of a novel inducer of protein-protein interactions based on aplyronine A

Abstract

ASJC Scopus subject areas

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