Development of practical synthesis of halichondrins

Ichiro Hayakawa

doi:10.5059/yukigoseikyokaishi.65.1225

Development of practical synthesis of halichondrins

Ichiro Hayakawa

School of Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Halichondrin B is a polyether macrolide that exhibits an extraordinary cytotoxicity in vitro and antitumor efficacy in vivo. A structurally simplified macrolactone right half segment of harichondrin B was identified to retain the potent cell growth inhibitory activity of the natural product in vitro. Kishi and coworkers developed a practical, an efficient and scalable synthesis of the right half segment of harichondrin B.

Original language	English
Pages (from-to)	1225-1226
Number of pages	2
Journal	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume	65
Issue number	12
DOIs	https://doi.org/10.5059/yukigoseikyokaishi.65.1225
Publication status	Published - Dec 2007

ASJC Scopus subject areas

Organic Chemistry

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10.5059/yukigoseikyokaishi.65.1225

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Development of practical synthesis of halichondrins

Abstract

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