Developmental delay in islet-1-positive motor neurons in chick spina bifida

Min Wang, Katsumi Mominoki, Masae Kinutani, Zhong Wang, Naoto Kobayashi, Tetsuya Shimokawa, Hiroaki Nabeka, Takashi Fujiwara, Seiji Matsuda

Research output: Contribution to journalComment/debatepeer-review

4 Citations (Scopus)


Spina bifida aperta (SBA) is a congenital malformation of the spinal cord with complications such as spinal ataxia and bowel and bladder dysfunction. We have developed a chick model with surgery-induced SBA that shows spinal ataxia after hatching. In the present study, motor neurons in the early stages in chicks with and without SBA were observed by immunohistochemical staining with a monoclonal antibody against Islet-1, a motor neuron marker. Delay in migration and maturation of motor neurons was observed in SBA. Although the final numbers of Islet-1-positive neurons in these two groups were not different, a defect in the production and elimination of excess motor neurons in the early developmental stages in the SBA group may be involved in the pathological mechanism of the motor complications of this disease.

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalJournal of Veterinary Medical Science
Issue number4
Publication statusPublished - Apr 2011


  • Animal model for human disease
  • Chick
  • Motor neurons
  • Neural cell differentiation
  • Spina bifida aperta

ASJC Scopus subject areas

  • General Veterinary


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