Diabetic nephropathy--recent advances in its mechanism and treatment

H. Makino, H. Sugimoto, K. Shikata

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


The elevated glomerular filtration rate that occurs in 25 to 40 percent of insulin-dependent diabetics has been proposed as having a role in the initiation and evolution of diabetic nephropathy. We report that both enhanced NO synthesis by ecNOS in afferent arterioles and glomerular endothelial cells and increased expression of IGF-1 receptor can cause glomerular hyperfiltration, and that upregulated expression of ICAM-1 can promote the intraglomerular infiltration of mononuclear cells, which were prevented by aldose reductase inhibitor. The results of United Kingdom Prospective Diabetes Study (UKPDS) will also be discussed.

Original languageEnglish
Pages (from-to)590-600
Number of pages11
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number3
Publication statusPublished - Mar 1999

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Diabetic nephropathy--recent advances in its mechanism and treatment'. Together they form a unique fingerprint.

Cite this