Dielectric behavior of the rabbit cornea as a measure of the healing process in injured epithelium

Y. Mokudai, M. Watanabe, M. Ando, H. Ueno

Research output: Contribution to journalArticlepeer-review


To correlate changes in the passive electrical properties of the rabbit cornea with quantitative grading of corneal injuries induced by topical application of 70% ethanol, we measured ocular tissue impedances using a surface electrode over the range of 104 ~ 108 Hz and followed their temporal changes for up to 17 days. Dielectric measurements on control eyes yielded a broad dispersion curve, which, in loss tangent terms, could be decomposed into two components: dispersion 1 on the low-frequency side and dispersion 2 on the high-frequency side. By defining the peak value of the total dispersion as P(t) and those of subdispersions 1 and 2 P1 and P2, the ratios, P1/P(t) and P2/P(t), were found to serve as useful indices. Upon appearance of corneal erosion due to ethanol, P1/P(t) markedly increased and returned to the control level with re-epithelialization of the cornea, and the time course of P2/P(t) showed a mirror image to that of P1/P(t). Both ratios correlated well with the erosion area determined photographically. These results indicate that dielectric spectroscopy is applicable to the assessment of the extent and severity of corneal injury.

Original languageEnglish
Pages (from-to)215-223
Number of pages9
JournalJournal of Japanese Ophthalmological Society
Issue number3
Publication statusPublished - 1994
Externally publishedYes


  • corneal epithelial injury
  • dielectric analysis
  • impedance
  • loss tangent
  • wound healing

ASJC Scopus subject areas

  • General Medicine


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