Abstract
To correlate changes in the passive electrical properties of the rabbit cornea with quantitative grading of corneal injuries induced by topical application of 70% ethanol, we measured ocular tissue impedances using a surface electrode over the range of 104 ~ 108 Hz and followed their temporal changes for up to 17 days. Dielectric measurements on control eyes yielded a broad dispersion curve, which, in loss tangent terms, could be decomposed into two components: dispersion 1 on the low-frequency side and dispersion 2 on the high-frequency side. By defining the peak value of the total dispersion as P(t) and those of subdispersions 1 and 2 P1 and P2, the ratios, P1/P(t) and P2/P(t), were found to serve as useful indices. Upon appearance of corneal erosion due to ethanol, P1/P(t) markedly increased and returned to the control level with re-epithelialization of the cornea, and the time course of P2/P(t) showed a mirror image to that of P1/P(t). Both ratios correlated well with the erosion area determined photographically. These results indicate that dielectric spectroscopy is applicable to the assessment of the extent and severity of corneal injury.
| Original language | English |
|---|---|
| Pages (from-to) | 215-223 |
| Number of pages | 9 |
| Journal | Journal of Japanese Ophthalmological Society |
| Volume | 98 |
| Issue number | 3 |
| Publication status | Published - 1994 |
| Externally published | Yes |
Keywords
- corneal epithelial injury
- dielectric analysis
- impedance
- loss tangent
- wound healing
ASJC Scopus subject areas
- Medicine(all)