Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction

Makiko Kawakami, Nobuhiro Harada, Mio Hiratsuka, Kiyoshi Kawai, Yoshimasa Nakamura

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


We found that both benzyl isothiocyanate (ITC) and phenyl ITC inhibited respiration in the mitochondria in an electrophilic reaction-dependent manner. ITC-induced mitochondrial swelling and cytochrome c release were prevented by cyclosporin A, indicating that they are mediated through the ITC moiety-dependent reaction to critical thiol groups for the opening of membrane permeability transition-dependent pores.

Original languageEnglish
Pages (from-to)2439-2444
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Issue number12
Publication statusPublished - 2005


  • Cytochrome c
  • Electrophile
  • Isothiocyanate
  • Membrane permeability transition
  • Mitochondria

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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