TY - JOUR
T1 - Difference in tolerance development to hypothermia and pentobarbital-induced sleep prolongating effect of 11-hydroxy-Δ8-tetrahydrocannabinol and 11-oxo-Δ8-tetrahydrocannabinol in mice
AU - Watanabe, Kazuhito
AU - Narimatsu, Shizuo
AU - Yamamoto, Ikuo
AU - Yoshimura, Hidetoshi
PY - 1982/1/8
Y1 - 1982/1/8
N2 - Daily administration (5 mg/kg i.v.) of 11-hydroxy-Δ8-tetrahydrocannabinol or 11-oxo-Δ8-tetrahydrocannabinol as well Δ8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development differed from one another. The sleeping times after the 8th injection of these cannabinoids were still significantly longer than those of the controls when no hypothermia was induced.
AB - Daily administration (5 mg/kg i.v.) of 11-hydroxy-Δ8-tetrahydrocannabinol or 11-oxo-Δ8-tetrahydrocannabinol as well Δ8-tetrahydrocannabinol quickly induced tolerance to their hypothermic effects in mice. Tolerance also developed to their pentobarbital-induced sleep prolongating effects. However, the degrees of tolerance development differed from one another. The sleeping times after the 8th injection of these cannabinoids were still significantly longer than those of the controls when no hypothermia was induced.
KW - 11-Hydroxy-Δ-tetrahydrocannabinol
KW - 11-Oxo-Δ-tetrahydrocannabinol
KW - Hypothermia
KW - Pentobarbital-induced sleeping time
KW - Tolerance
KW - Δ-Tetrahydrocannabinol
UR - http://www.scopus.com/inward/record.url?scp=0020082041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020082041&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(82)90535-0
DO - 10.1016/0014-2999(82)90535-0
M3 - Article
C2 - 6277654
AN - SCOPUS:0020082041
SN - 0014-2999
VL - 77
SP - 53
EP - 56
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -