Different Expression Patterns of beta-Defensins in Human Squamous Cell Carcinomas

Tomohito Yoshimoto; Tomoichiro Yamaai; Nobuyoshi Mizukawa; Koichi Sawaki; Makoto Nakano; Eiki Yamachika; Toshio Sugahara

Different Expression Patterns of beta-Defensins in Human Squamous Cell Carcinomas

Tomohito Yoshimoto, Tomoichiro Yamaai, Nobuyoshi Mizukawa, Koichi Sawaki, Makoto Nakano, Eiki Yamachika, Toshio Sugahara

University Hospital

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The expression of human β-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.

Original language	English
Pages (from-to)	4629-4633
Number of pages	5
Journal	Anticancer research
Volume	23
Issue number	6 C
Publication status	Published - Nov 2003

Keywords

Defensin
Oral tumor
Squamous cell carcinomas
β defensin-2
β defensin-3

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The expression of human β-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.",

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AU - Yoshimoto, Tomohito

AU - Yamaai, Tomoichiro

AU - Mizukawa, Nobuyoshi

AU - Sawaki, Koichi

AU - Nakano, Makoto

AU - Yamachika, Eiki

AU - Sugahara, Toshio

PY - 2003/11

Y1 - 2003/11

N2 - The expression of human β-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.

AB - The expression of human β-defensin genes in oral squamous cell carcinomas(SCCs) was demonstrated by in situ hybridization. The expression of HBD-2 was observed not only in the inflamed lesions with bacterial infection but also in the non-inflamed carcinomas themselves (evident in 15 out of 20 carcinomas). However, HBD-3 expression was found in only 4 out of 20 SCCs. In the normal oral epithelia, the expression of HBD-2 and HBD-3 was only detected in the areas adjacent to the SCCs. These results suggest that HBD-2 might play a role in SCCs, which is different from the native defensive role of these proteins. HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells.

KW - Defensin

KW - Oral tumor

KW - Squamous cell carcinomas

KW - β defensin-2

KW - β defensin-3

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IS - 6 C

ER -

Different Expression Patterns of beta-Defensins in Human Squamous Cell Carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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