Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

Leonardo H. Tonelli; Shigeru Maeda; Kimberly L. Rapp; Esther M. Sternberg

doi:10.1016/S0165-5728(03)00171-1

Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

Leonardo H. Tonelli, Shigeru Maeda, Kimberly L. Rapp, Esther M. Sternberg

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.

Original language	English
Pages (from-to)	126-136
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	140
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(03)00171-1
Publication status	Published - Jul 2003
Externally published	Yes

Keywords

Cerebral cortex
Circumventricular organs
Cytokines
Hypothalamus
Inbred rats

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(03)00171-1

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title = "Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides",

abstract = "The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.",

keywords = "Cerebral cortex, Circumventricular organs, Cytokines, Hypothalamus, Inbred rats",

author = "Tonelli, {Leonardo H.} and Shigeru Maeda and Rapp, {Kimberly L.} and Sternberg, {Esther M.}",

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T1 - Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

AU - Tonelli, Leonardo H.

AU - Maeda, Shigeru

AU - Rapp, Kimberly L.

AU - Sternberg, Esther M.

PY - 2003/7

Y1 - 2003/7

N2 - The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.

AB - The expression of interleukin-1 beta (IL-1β) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1β mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1β mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1β mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.

KW - Cerebral cortex

KW - Circumventricular organs

KW - Cytokines

KW - Hypothalamus

KW - Inbred rats

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Differential induction of interleukin-I β mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides

Abstract

Keywords

ASJC Scopus subject areas

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