Diffuse Cerebrospinal Gliomatosis Case Report

Yamamoto Yoshihiro, Tsuji Takehisa, Suga Masakazu, Sunami Norio, Yamamoto Yuji, Kunishio Katsuzo, Sonobe Hiroshi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A 65-year-old male was admitted with memory and gait disturbance. A computed tomography (CT) scan showed bilateral, diffuse, low-density areas with two round, slightly enhanced masses. T1-weighted magnetic resonance image revealed a low-intensity area in the left paraventricular region, which converted to increased signal intensity, extending to the right paraventricular region through the splenium, on T2-weighted images The tumor was diagnosed as glioblastoma multiforme after needle biopsy and treated by irradiation and chemotherapy. Seven months after admission, a CT scan revealed subependymal infiltration of the tumor with spotty calcification. He died of respiratory complications 11 months after the onset of symptoms. The autopsy showed brain swelling with flattened gyri. Horizontal sections of the brain showed diffuse enlargement of the white matter and basal ganglia with scattered hemorrhage and necrosis. Microscopically, the lesion was farmore extensive and diffuse than was suspected from gross examination. Wide glial tumor cell infiltration was observed in the cerebral hemispheres, basal ganglia, brainstem, cerebellum, and even the cervical spinal cord with minimum destruction of the pre-existing architecture. Calcification was found around the thrombosed vessels and necrotic lesions. The clinical diagnosis and histological features of gliomatosis cerebri are discussed with reference to reported cases.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
Journalneurologia medico-chirurgica
Issue number13
Publication statusPublished - 1991
Externally publishedYes


  • computed tomography
  • diffuse cerebrospinal gliomatosis
  • gliomatosis cerebri
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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