Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula

Tomoyasu Tachibana; Yorihisa Orita; Masayoshi Fujisawa; Yasushi Hiramatsu; Yuya Ogawara; Yuko Matsuyama; Iku Abe; Kaori Uchino; Hirofumi Morishita; Tetsuji Nobuhisa; Koichi Uesaka; Kazunori Nishizaki

doi:10.1007/s10388-013-0408-2

Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula

Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Yasushi Hiramatsu, Yuya Ogawara, Yuko Matsuyama, Iku Abe, Kaori Uchino, Hirofumi Morishita, Tetsuji Nobuhisa, Koichi Uesaka, Kazunori Nishizaki

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We describe a rare case of thyroidal Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV⁺DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically, the thyroid lesion showed extensive necrosis, including a few Ziehl–Neelsen-positive substances. No evidence of tuberculosis was detected by any other examinations. While performing examinations, left recurrent nerve palsy and a tumorous lesion in the pharynx appeared. Computed tomography and gastrointestinal fiberscopy revealed esophageal fistula. Biopsy specimens from the pharyngeal lesion showed diffuse proliferation of large atypical lymphoid cells that were strongly positive for CD20 and EBV early RNAs. The final diagnosis was thyroidal EBV⁺DLBCLe with infiltration of surrounding organs. The esophageal fistula had healed 6 months after beginning treatment of EBV⁺DLBCLe.

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	Esophagus
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/s10388-013-0408-2
Publication status	Published - Jan 18 2015
Externally published	Yes

Keywords

Diffuse large B-cell lymphoma
Esophageal fistula
Thyroid

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10388-013-0408-2

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title = "Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula",

abstract = "We describe a rare case of thyroidal Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically, the thyroid lesion showed extensive necrosis, including a few Ziehl–Neelsen-positive substances. No evidence of tuberculosis was detected by any other examinations. While performing examinations, left recurrent nerve palsy and a tumorous lesion in the pharynx appeared. Computed tomography and gastrointestinal fiberscopy revealed esophageal fistula. Biopsy specimens from the pharyngeal lesion showed diffuse proliferation of large atypical lymphoid cells that were strongly positive for CD20 and EBV early RNAs. The final diagnosis was thyroidal EBV+DLBCLe with infiltration of surrounding organs. The esophageal fistula had healed 6 months after beginning treatment of EBV+DLBCLe.",

keywords = "Diffuse large B-cell lymphoma, Esophageal fistula, Thyroid",

author = "Tomoyasu Tachibana and Yorihisa Orita and Masayoshi Fujisawa and Yasushi Hiramatsu and Yuya Ogawara and Yuko Matsuyama and Iku Abe and Kaori Uchino and Hirofumi Morishita and Tetsuji Nobuhisa and Koichi Uesaka and Kazunori Nishizaki",

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year = "2015",

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doi = "10.1007/s10388-013-0408-2",

language = "English",

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T1 - Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula

AU - Tachibana, Tomoyasu

AU - Orita, Yorihisa

AU - Fujisawa, Masayoshi

AU - Hiramatsu, Yasushi

AU - Ogawara, Yuya

AU - Matsuyama, Yuko

AU - Abe, Iku

AU - Uchino, Kaori

AU - Morishita, Hirofumi

AU - Nobuhisa, Tetsuji

AU - Uesaka, Koichi

AU - Nishizaki, Kazunori

PY - 2015/1/18

Y1 - 2015/1/18

N2 - We describe a rare case of thyroidal Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically, the thyroid lesion showed extensive necrosis, including a few Ziehl–Neelsen-positive substances. No evidence of tuberculosis was detected by any other examinations. While performing examinations, left recurrent nerve palsy and a tumorous lesion in the pharynx appeared. Computed tomography and gastrointestinal fiberscopy revealed esophageal fistula. Biopsy specimens from the pharyngeal lesion showed diffuse proliferation of large atypical lymphoid cells that were strongly positive for CD20 and EBV early RNAs. The final diagnosis was thyroidal EBV+DLBCLe with infiltration of surrounding organs. The esophageal fistula had healed 6 months after beginning treatment of EBV+DLBCLe.

AB - We describe a rare case of thyroidal Epstein–Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically, the thyroid lesion showed extensive necrosis, including a few Ziehl–Neelsen-positive substances. No evidence of tuberculosis was detected by any other examinations. While performing examinations, left recurrent nerve palsy and a tumorous lesion in the pharynx appeared. Computed tomography and gastrointestinal fiberscopy revealed esophageal fistula. Biopsy specimens from the pharyngeal lesion showed diffuse proliferation of large atypical lymphoid cells that were strongly positive for CD20 and EBV early RNAs. The final diagnosis was thyroidal EBV+DLBCLe with infiltration of surrounding organs. The esophageal fistula had healed 6 months after beginning treatment of EBV+DLBCLe.

KW - Diffuse large B-cell lymphoma

KW - Esophageal fistula

KW - Thyroid

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Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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