Direct Intracerebral Invasion from Skull Metastasis of Large Cell Lung Cancer

Akio Hiraki, Masahiro Tabata, Hiroshi Ueoka, Katsuyuki Kiura, Takuo Shibayama, Hiromichi Yamane, Mine Harada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A 56-year-old Japanese woman was referred to us for the treatment of lung cancer. On admission, the patient showed multiple bone metastases, including the skull, without brain metastasis. During chemoradiotherapy for the primary tumor and bone metastasis involving the thoracic spine, she suffered a fatal intracerebral hemorrhage. Since the patient had no risk factors for intracerebral hemorrhage, the skull bone metastasis was thought to be responsible for this event. At autopsy, penetration of the metastatic tumor from the skull bone into the dura, with direct invasion of the brain tissue, was confirmed histologically. A hematoma also was identified at the same site adjacent to the skull bone metastasis. To our knowledge, direct tumor invasion to the brain from a skull metastasis of non-small cell lung cancer has not been previously reported.

Original languageEnglish
Pages (from-to)720-723
Number of pages4
JournalInternal Medicine
Issue number10
Publication statusPublished - 1997


  • Adverse effect
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Internal Medicine


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