Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases

M. Yamamoto, J. Kaburaki, M. Kuwana, S. Kawai, E. Matsuura, Y. Ikeda

Research output: Contribution to journalArticlepeer-review


Cofactor-dependent IgG anti-cardiolipin antibodies (ACA) were examined in sera from various connective tissue diseases by ELISA using purified human beta 2-glycoprotein I. The frequency and titer of cofactor-dependent IgG ACA were higher in patients with SLE than in those with other diseases, such as RA, SSc, PM/DM, overlap syndrome, and MCTD. The predictive value for SLE was 95%. However, all of the ACA were not cofactor-dependent in SLE patients. These results indicated that cofactor-dependent IgG ACA were specific for SLE patients, but the epitopes of ACA were heterogenous, depending on various clinical manifestations.

Original languageEnglish
Pages (from-to)879-881
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Issue number7
Publication statusPublished - Jul 1993
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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