TY - JOUR
T1 - Division modes and physical asymmetry in cerebral cortex progenitors
AU - Delaunay, Delphine
AU - Kawaguchi, Ayano
AU - Dehay, Colette
AU - Matsuzaki, Fumio
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Neural stem cells go through a sequence of timely regulated gene expression and pattern of division mode to generate diverse neurons during brain development. During vertebrate cerebral cortex development, neural stem cells begin with proliferative symmetric divisions, subsequently undergo neurogenic asymmetric divisions, and finally gliogenic divisions. In this review, we explore the relationship between stem cell versus neural fate specification and the division mode. Specifically, we discuss recent findings on the mechanisms of asymmetric divisions, division mode, and developmental progression of neural progenitor identity.
AB - Neural stem cells go through a sequence of timely regulated gene expression and pattern of division mode to generate diverse neurons during brain development. During vertebrate cerebral cortex development, neural stem cells begin with proliferative symmetric divisions, subsequently undergo neurogenic asymmetric divisions, and finally gliogenic divisions. In this review, we explore the relationship between stem cell versus neural fate specification and the division mode. Specifically, we discuss recent findings on the mechanisms of asymmetric divisions, division mode, and developmental progression of neural progenitor identity.
UR - http://www.scopus.com/inward/record.url?scp=85003848879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85003848879&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2016.11.009
DO - 10.1016/j.conb.2016.11.009
M3 - Review article
C2 - 27978481
AN - SCOPUS:85003848879
SN - 0959-4388
VL - 42
SP - 75
EP - 83
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -