Dodeca-CLE as peptides as suppressors of plant stem cell differentiation

Yasuko Ito; Ikuko Nakanomyo; Hiroyasu Motose; Kuninori Iwamoto; Shinichiro Sawa; Naoshi Dohmae; Hiroo Fukuda

doi:10.1126/science.1128436

Dodeca-CLE as peptides as suppressors of plant stem cell differentiation

Yasuko Ito, Ikuko Nakanomyo, Hiroyasu Motose, Kuninori Iwamoto, Shinichiro Sawa, Naoshi Dohmae, Hiroo Fukuda

Research output: Contribution to journal › Article › peer-review

503 Citations (Scopus)

Abstract

In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidapsis. The dodecapeptide suppresses xylem cell development at a concentration of 10^-11 M and promotes cell division. An application, corresponding to all 26 Arabidapsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.

Original language	English
Pages (from-to)	842-845
Number of pages	4
Journal	Science
Volume	313
Issue number	5788
DOIs	https://doi.org/10.1126/science.1128436
Publication status	Published - Aug 11 2006
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1128436

Cite this

@article{94e5b824aace4120bc70c13b84de0ef2,

title = "Dodeca-CLE as peptides as suppressors of plant stem cell differentiation",

abstract = "In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidapsis. The dodecapeptide suppresses xylem cell development at a concentration of 10-11 M and promotes cell division. An application, corresponding to all 26 Arabidapsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.",

author = "Yasuko Ito and Ikuko Nakanomyo and Hiroyasu Motose and Kuninori Iwamoto and Shinichiro Sawa and Naoshi Dohmae and Hiroo Fukuda",

year = "2006",

month = aug,

day = "11",

doi = "10.1126/science.1128436",

language = "English",

volume = "313",

pages = "842--845",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5788",

}

TY - JOUR

T1 - Dodeca-CLE as peptides as suppressors of plant stem cell differentiation

AU - Ito, Yasuko

AU - Nakanomyo, Ikuko

AU - Motose, Hiroyasu

AU - Iwamoto, Kuninori

AU - Sawa, Shinichiro

AU - Dohmae, Naoshi

AU - Fukuda, Hiroo

PY - 2006/8/11

Y1 - 2006/8/11

N2 - In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidapsis. The dodecapeptide suppresses xylem cell development at a concentration of 10-11 M and promotes cell division. An application, corresponding to all 26 Arabidapsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.

AB - In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidapsis. The dodecapeptide suppresses xylem cell development at a concentration of 10-11 M and promotes cell division. An application, corresponding to all 26 Arabidapsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.

UR - http://www.scopus.com/inward/record.url?scp=33747144246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747144246&partnerID=8YFLogxK

U2 - 10.1126/science.1128436

DO - 10.1126/science.1128436

M3 - Article

C2 - 16902140

AN - SCOPUS:33747144246

SN - 0036-8075

VL - 313

SP - 842

EP - 845

JO - Science

JF - Science

IS - 5788

ER -

Dodeca-CLE as peptides as suppressors of plant stem cell differentiation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this