Dodeca-CLE as peptides as suppressors of plant stem cell differentiation

Yasuko Ito, Ikuko Nakanomyo, Hiroyasu Motose, Kuninori Iwamoto, Shinichiro Sawa, Naoshi Dohmae, Hiroo Fukuda

Research output: Contribution to journalArticlepeer-review

503 Citations (Scopus)


In plants and animals, small peptide ligands that signal in cell-cell communication have been suggested to be a crucial component of development. A bioassay of single-cell transdifferentation demonstrates that a dodecapeptide with two hydroxyproline residues is the functional product of genes from the CLE family, which includes CLAVATA3 in Arabidapsis. The dodecapeptide suppresses xylem cell development at a concentration of 10-11 M and promotes cell division. An application, corresponding to all 26 Arabidapsis CLE protein family members, of synthetic dodecapeptides reveals two counteracting signaling pathways involved in stem cell fate.

Original languageEnglish
Pages (from-to)842-845
Number of pages4
Issue number5788
Publication statusPublished - Aug 11 2006
Externally publishedYes

ASJC Scopus subject areas

  • General


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