TY - JOUR
T1 - Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan
T2 - A multicenter, randomized controlled trial
AU - Kita, Fumiyo
AU - Hinotsu, Shiro
AU - Yorifuji, Tohru
AU - Urushihara, Hisashi
AU - Shimakawa, Tetsuro
AU - Kishida, Kenji
AU - Wakazono, Yoshihiro
AU - Yamauchi, Eiko
AU - Sasaki, Hiroshi
AU - Nakahata, Tatsutoshi
AU - Kawakami, Koji
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: the Inamori Foundation (2009), Kyoto, Japan, supported this work.
Publisher Copyright:
© 2012 APJPH.
PY - 2015/3/4
Y1 - 2015/3/4
N2 - Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan. In this study, the authors assessed the efficacy of domperidone prescription in combination with oral rehydration treatment (ORT) in the treatment of vomiting during acute gastroenteritis in children during the early period. They performed a prospective multicenter randomized trial in Japan. Patients received either ORT or ORT and domperidone prescription. The primary outcome was the proportion of patients who had vomiting during the first 2 hours after randomization. A total of 56 children were eligible; 24 received ORT alone, and 32 received ORT and prescribed domperidone suppository. Results showed that 27.3% of children in the ORT group vomited as compared with 20.7% of children in the ORT and domperidone group (P =.41). In this study, it appears that domperidone in combination with ORT in the treatment of acute gastroenteritis does not reduce vomiting in the early period.
AB - Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan. In this study, the authors assessed the efficacy of domperidone prescription in combination with oral rehydration treatment (ORT) in the treatment of vomiting during acute gastroenteritis in children during the early period. They performed a prospective multicenter randomized trial in Japan. Patients received either ORT or ORT and domperidone prescription. The primary outcome was the proportion of patients who had vomiting during the first 2 hours after randomization. A total of 56 children were eligible; 24 received ORT alone, and 32 received ORT and prescribed domperidone suppository. Results showed that 27.3% of children in the ORT group vomited as compared with 20.7% of children in the ORT and domperidone group (P =.41). In this study, it appears that domperidone in combination with ORT in the treatment of acute gastroenteritis does not reduce vomiting in the early period.
KW - antiemetics
KW - children
KW - gastroenteritis
KW - oral rehydration treatment
KW - randomized clinical study
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U2 - 10.1177/1010539511425701
DO - 10.1177/1010539511425701
M3 - Article
C2 - 22234829
AN - SCOPUS:84926304547
SN - 1010-5395
VL - 27
SP - NP174-NP183
JO - Asia-Pacific Journal of Public Health
JF - Asia-Pacific Journal of Public Health
IS - 2
ER -
