Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

K. Nagafuji; T. Eto; S. Hayashi; K. Oshima; Y. Maeda; H. Gondo; T. Inamura; Y. Niho

doi:10.1038/sj.bmt.1701205

Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

K. Nagafuji, T. Eto, S. Hayashi, K. Oshima, Y. Maeda, H. Gondo, T. Inamura, Y. Niho

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 10⁶ CD3⁺ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

Original language	English
Pages (from-to)	1155-1158
Number of pages	4
Journal	Bone Marrow Transplantation
Volume	21
Issue number	11
DOIs	https://doi.org/10.1038/sj.bmt.1701205
Publication status	Published - 1998

Keywords

Central nervous system
Donor lymphocyte transfusion
Epstein-Barr virus-associated lymphoproliferative disorder

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1701205

Cite this

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title = "Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain",

abstract = "EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.",

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AU - Nagafuji, K.

AU - Eto, T.

AU - Hayashi, S.

AU - Oshima, K.

AU - Maeda, Y.

AU - Gondo, H.

AU - Inamura, T.

AU - Niho, Y.

PY - 1998

Y1 - 1998

N2 - EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

AB - EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

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KW - Epstein-Barr virus-associated lymphoproliferative disorder

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Donor lymphocyte transfusion for the treatment of Epstein-Barr virus-associated lymphoproliferative disorder of the brain

Abstract

Keywords

ASJC Scopus subject areas

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