Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

Yeunhwa Gu, Chien Sheng Huang, Tota Inoue, Takenori Yamashita, Torao Ishida, Ki Mun Kang, Atsunori Nakao

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using senescence-accelerated prone mouse 8 (SAMP8), which exhibits early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability seen in SAMP8 as assessed by a water maze test and was associated with increased brain serotonin levels and elevated serum antioxidant activity. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of our results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.

Original languageEnglish
Pages (from-to)269-276
Number of pages8
Journaljournal of clinical biochemistry and nutrition
Issue number3
Publication statusPublished - May 2010
Externally publishedYes


  • Cognitive disorder
  • Hydrogen water
  • Magnesium stick
  • Oxidative stress
  • Senescence

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry


Dive into the research topics of 'Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice'. Together they form a unique fingerprint.

Cite this