Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy

Shingo Iwami; Yasuhiro Takeuchi; Yoshiharu Miura; Toru Sasaki; Tsuyoshi Kajiwara

doi:10.1016/j.jtbi.2007.01.020

Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy

Shingo Iwami, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki, Tsuyoshi Kajiwara

School of Engineering

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The mechanisms of autoimmune disease have remained puzzling for a long time. Here we construct a simple mathematical model for autoimmune disease based on the personal immune response function and the target cell growth function. We show that these two functions are sufficient to capture the essence of autoimmune disease and can explain characteristic symptom phases such as tolerance, repeated flare-ups and dormancy. Our results strongly suggest that a more complete understanding of these two functions will underlie the development of an effective therapy for autoimmune disease.

Original language	English
Pages (from-to)	646-659
Number of pages	14
Journal	Journal of Theoretical Biology
Volume	246
Issue number	4
DOIs	https://doi.org/10.1016/j.jtbi.2007.01.020
Publication status	Published - Jun 21 2007

Keywords

Autoimmune disease
Dormancy
Flare-up
Mathematical model
Tolerance

ASJC Scopus subject areas

Statistics and Probability
Modelling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1016/j.jtbi.2007.01.020

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abstract = "The mechanisms of autoimmune disease have remained puzzling for a long time. Here we construct a simple mathematical model for autoimmune disease based on the personal immune response function and the target cell growth function. We show that these two functions are sufficient to capture the essence of autoimmune disease and can explain characteristic symptom phases such as tolerance, repeated flare-ups and dormancy. Our results strongly suggest that a more complete understanding of these two functions will underlie the development of an effective therapy for autoimmune disease.",

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AU - Kajiwara, Tsuyoshi

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Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy

Abstract

Keywords

ASJC Scopus subject areas

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