TY - JOUR
T1 - E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein
AU - Hattori, Takako
AU - Kishino, Tetsuya
AU - Stephen, Shelley
AU - Eberspaecher, Heidi
AU - Maki, Sayumi
AU - Takigawa, Masaharu
AU - De Crombrugghe, Benoit
AU - Yasuda, Hideyo
PY - 2013/12/6
Y1 - 2013/12/6
N2 - Background: Although the ubiquitin-proteasome pathway is thought to regulate the level of SOX9, the ubiquitin ligase involved has not yet been determined. Results: E6-AP/UBE3A was found to bind and ubiquitinate SOX9. Conclusion: E6-AP/UBE3A functions as a ubiquitin ligase toward SOX9 both in vitro and in vivo. Significance: These data provide the regulatory mechanism of the SOX9 level in chondrocytes by ubiquitin ligase.
AB - Background: Although the ubiquitin-proteasome pathway is thought to regulate the level of SOX9, the ubiquitin ligase involved has not yet been determined. Results: E6-AP/UBE3A was found to bind and ubiquitinate SOX9. Conclusion: E6-AP/UBE3A functions as a ubiquitin ligase toward SOX9 both in vitro and in vivo. Significance: These data provide the regulatory mechanism of the SOX9 level in chondrocytes by ubiquitin ligase.
UR - http://www.scopus.com/inward/record.url?scp=84890283576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890283576&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.486795
DO - 10.1074/jbc.M113.486795
M3 - Article
C2 - 24155239
AN - SCOPUS:84890283576
SN - 0021-9258
VL - 288
SP - 35138
EP - 35148
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 49
ER -