E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein

Takako Hattori, Tetsuya Kishino, Shelley Stephen, Heidi Eberspaecher, Sayumi Maki, Masaharu Takigawa, Benoit De Crombrugghe, Hideyo Yasuda

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Background: Although the ubiquitin-proteasome pathway is thought to regulate the level of SOX9, the ubiquitin ligase involved has not yet been determined. Results: E6-AP/UBE3A was found to bind and ubiquitinate SOX9. Conclusion: E6-AP/UBE3A functions as a ubiquitin ligase toward SOX9 both in vitro and in vivo. Significance: These data provide the regulatory mechanism of the SOX9 level in chondrocytes by ubiquitin ligase.

Original languageEnglish
Pages (from-to)35138-35148
Number of pages11
JournalJournal of Biological Chemistry
Issue number49
Publication statusPublished - Dec 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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