TY - JOUR
T1 - Ectopic cardiovascular fat in middle-aged men
T2 - Effects of race/ethnicity, overall and central adiposity. The ERA JUMP study
AU - El Khoudary, S. R.
AU - Shin, C.
AU - Masaki, K.
AU - Miura, K.
AU - Budoff, M.
AU - Edmundowicz, D.
AU - Kadowaki, S.
AU - Barinas-Mitchell, E.
AU - El-Saed, A.
AU - Fujiyoshi, A.
AU - Evans, R. W.
AU - Hisamatsu, T.
AU - Ohkubo, T.
AU - Willcox, B. J.
AU - Kuller, L. H.
AU - Ueshima, H.
AU - Sekikawa, A.
N1 - Funding Information:
This work was supported by grants HL068200 and HL071561 from the National Institutes of Health, Bethesda, MD, USA, Korea Center for Disease Control and Prevention (Government budget code: 2004-E71001-00, 205-E71001-00) and grants B 16790335, A 13307016, 17209023, 21249043, A 25253046 and B 23390174 from the Japanese Ministry of Education, Culture, Sports, Science and Technology (Tokyo, Japan).
Publisher Copyright:
© 2015 Macmillan Publishers Limited.
PY - 2015/3/12
Y1 - 2015/3/12
N2 - Background/objectives:Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.Subjects/methods:Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).Results:Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values<0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value<0.05).Conclusions:Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.
AB - Background/objectives:Higher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD. Significant racial/ethnic differences exist for overall and central adiposity measures, which are known to be associated with ECF volumes. Whether racial/ethnic differences also exist for ECF volumes and their associations with these adiposity measures remain unclear.Subjects/methods:Body mass index (BMI), computerized tomography-measured ECF volumes (epicardial, pericardial and their summation) and visceral adipose tissue (VAT) were examined in a community-based sample of 1199 middle-aged men (24.2% Caucasians, 7.0% African-Americans, 23.6% Japanese-Americans, 22.0% Japanese, 23.2% Koreans).Results:Significant racial/ethnic differences existed in ECF volumes and their relationships with BMI and VAT. ECF volumes were the highest among Japanese-Americans and the lowest among African-Americans. The associations of BMI and VAT with ECF differed by racial/ethnic groups. Compared with Caucasians, for each 1-unit increase in BMI, African-Americans had lower, whereas Koreans had higher increases in ECF volumes (P-values<0.05 for both). Meanwhile, compared with Caucasians, for each 1-unit increase in log-transformed VAT, African-Americans, Japanese-Americans and Japanese had similar increases, whereas Koreans had a lower increase in ECF volumes (P-value<0.05).Conclusions:Racial/ethnic groups differed in their propensity to accumulate ECF at increasing level of overall and central adiposity. Future studies should evaluate whether reducing central adiposity or overall weight will decrease ECF volumes more in certain racial/ethnic groups. Evaluating these questions might help in designing race-specific prevention strategy of CHD risk associated with higher ECF.
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U2 - 10.1038/ijo.2014.154
DO - 10.1038/ijo.2014.154
M3 - Article
C2 - 25109783
AN - SCOPUS:84924730765
SN - 0307-0565
VL - 39
SP - 488
EP - 494
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 3
ER -
