Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

Feng Lu; Takehiro Nakamura; Tetsuhiko Toyoshima; Yanan Liu; Kazuyuki Hirooka; Nobuyuki Kawai; Naohiko Okabe; Fumio Shiraga; Takashi Tamiya; Osamu Miyamoto; Richard F. Keep; Toshifumi Itano

doi:10.1016/j.neulet.2011.10.041

Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

Feng Lu, Takehiro Nakamura, Tetsuhiko Toyoshima, Yanan Liu, Kazuyuki Hirooka, Nobuyuki Kawai, Naohiko Okabe, Fumio Shiraga, Takashi Tamiya, Osamu Miyamoto, Richard F. Keep, Toshifumi Itano

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

Original language	English
Pages (from-to)	28-32
Number of pages	5
Journal	Neuroscience Letters
Volume	506
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.10.041
Publication status	Published - Jan 6 2012

Keywords

Behavior
Gerbil
Ischemia
Oxidation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2011.10.041

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Lu, F., Nakamura, T., Toyoshima, T., Liu, Y., Hirooka, K., Kawai, N., Okabe, N., Shiraga, F., Tamiya, T., Miyamoto, O., Keep, R. F., & Itano, T. (2012). Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils. Neuroscience Letters, 506(1), 28-32. https://doi.org/10.1016/j.neulet.2011.10.041

Lu, F, Nakamura, T, Toyoshima, T, Liu, Y, Hirooka, K, Kawai, N, Okabe, N, Shiraga, F, Tamiya, T, Miyamoto, O, Keep, RF & Itano, T 2012, 'Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils', Neuroscience Letters, vol. 506, no. 1, pp. 28-32. https://doi.org/10.1016/j.neulet.2011.10.041

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title = "Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils",

abstract = "The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.",

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author = "Feng Lu and Takehiro Nakamura and Tetsuhiko Toyoshima and Yanan Liu and Kazuyuki Hirooka and Nobuyuki Kawai and Naohiko Okabe and Fumio Shiraga and Takashi Tamiya and Osamu Miyamoto and Keep, {Richard F.} and Toshifumi Itano",

note = "Funding Information: This study was supported by a grant-in-aid for scientific research from the Japanese Society for the Promotion of Science . Edaravone was a kind gift from Mitubishi Tanabe Pharma Corp, Osaka, Japan.",

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AU - Liu, Yanan

AU - Hirooka, Kazuyuki

AU - Kawai, Nobuyuki

AU - Okabe, Naohiko

AU - Shiraga, Fumio

AU - Tamiya, Takashi

AU - Miyamoto, Osamu

AU - Keep, Richard F.

AU - Itano, Toshifumi

N1 - Funding Information: This study was supported by a grant-in-aid for scientific research from the Japanese Society for the Promotion of Science . Edaravone was a kind gift from Mitubishi Tanabe Pharma Corp, Osaka, Japan.

PY - 2012/1/6

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N2 - The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

AB - The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3. mg/kg; i.p.) 30. min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5. min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), oxidative stress markers, were also examined to assess the anti-oxidative effects of edaravone. Edaravone treatment significantly inhibited both lipid and DNA oxidative damage 72. h after ischemia, and decreased neuronal damage. Edaravone also significantly reduced the locomotor activity deficit 72. h after ischemia and improved memory impairment. These findings suggest that edaravone inhibits oxidative stress and attenuates neuronal damage induced by transient forebrain ischemia in gerbils and which may contribute to improvements in behavioral deficits.

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Edaravone, a free radical scavenger, attenuates behavioral deficits following transient forebrain ischemia by inhibiting oxidative damage in gerbils

Abstract

Keywords

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