Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain

Isao Yokoi; Takehiko Itoh; Katsumi Yufu; Kenji Akiyama; Michiyoshi Satoh; Shinji Murakami; Hideaki Kabuto; Akitane Mori

doi:10.1007/BF00966595

Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain

Isao Yokoi, Takehiko Itoh, Katsumi Yufu, Kenji Akiyama, Michiyoshi Satoh, Shinji Murakami, Hideaki Kabuto, Akitane Mori

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

Original language	English
Pages (from-to)	1155-1159
Number of pages	5
Journal	Neurochemical Research
Volume	16
Issue number	10
DOIs	https://doi.org/10.1007/BF00966595
Publication status	Published - Oct 1991

Keywords

2′-guanidinoethanol
GABA antagonist
catecholamine
monoamine metabolisms

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1007/BF00966595

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title = "Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain",

abstract = "The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.",

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author = "Isao Yokoi and Takehiko Itoh and Katsumi Yufu and Kenji Akiyama and Michiyoshi Satoh and Shinji Murakami and Hideaki Kabuto and Akitane Mori",

year = "1991",

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AU - Akiyama, Kenji

AU - Satoh, Michiyoshi

AU - Murakami, Shinji

AU - Kabuto, Hideaki

AU - Mori, Akitane

PY - 1991/10

Y1 - 1991/10

N2 - The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

AB - The contents of monoamines and their metabolites in rat brains 3 hours after the intracerebroventricular injection of 6 μmol of 2-guanidino-ethanol (GEt) were measured by HPLC. GEt which is a configurational analogue of 4-aminobutanoic acid (GABA) induced severe running fits and tonic-clonic convulsions as well as epileptic discharges. In GEt-administered rats, dopamine (DA) decreased in the cortex, hippocampus and hypothalamus. 3,4-Dihydroxyphenylacetic acid (DOPAC) increased to about the same level in all brain regions, therefore the distribution of DOPAC appeared to be homogeneous in the brain. The homovanillic acid levels also increased in the striatum and hippocampus. No significant change in the norepinephrine contents was observed in any region. The turnover ratio of DA increased significantly except in the striatum. Serotonin levels increased in the hypothalamus and midbrain by GEt administration, though 5-hydroxyindoleacetic acid levels showed no change in any of the brain regions. These data suggest that the activity of dopaminergic and serotonergic neurons are increased by GEt.

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Effect of 2-guanidinoethanol on levels of monoamines and their metabolites in the rat brain

Abstract

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